Effects of atrial epicardial adipose tissue on electrical and structural remodeling on atrial fibrillation

• Project/Area Number: 25860626
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: Nihon University
• Principal Investigator: OKUMURA Yasuo 日本大学, 医学部, 助教 (20624159)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2014: ¥390,000 (Direct Cost: ¥300,000、Indirect Cost: ¥90,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 心房細動 / 心房周囲脂肪 / 高脂肪食 / 電気的リモデリング / カテーテルアブレーション / メタボリック症候群 / 肥満

Outline of Final Research Achievements

In obese pigs which fed a high-fat diet, pulmonary vein electrical refractory periods were significantly shorter and atrial fibrillation lasted longer than in the control group, which fed a normal diet. However, no histopathologic characteristics differed between the groups. These data suggests that the shorter pulmonary vein electrical refractory periods observed in response to the high-fat diet increased vulnerability to atrial fibrillation, and these electrophysiologic characteristics may underlie obesity-related atrial fibrillation. We also elucidated that left atrial ablation guided by 3-dimensional reconstructed epicardial adipose tissue CT image following pulmonary vein isolation provided a favorable clinical outcome after ablation in patients with persistent atrial fibrillation. This suggested that epicardial adipose tissue had potentially involved a vulnerable substrate for atrial fibrillation.

Research Products

• [Journal Article] Epicardial adipose tissue-based defragmentation approach to persistent atrial fibrillation: its impact on complex fractionated electrogram and the ablation outcome (2014)
  • Author(s): Shiro Nakahara, Yuichi Hori, Sayuki Kobayashi, Yoshihiko Sakai, Isao Taguchi, Kan Takayanagi, Koichi Nagashima, Kazumasa Sonoda, Rikitake Kogawa, Naoko Sasaki, Ichiro Watanabe, Yasuo Okumura
  • Journal Title: Heart Rhythm Volume: 11 Issue: 8 Pages: 1343-1351
  • DOI: 10.1016/j.hrthm.2014.04.040
  • Peer Reviewed / Open Access
• [Journal Article] 心房細動持続における心房周囲脂肪の役割 (2014)
  • Author(s): 奥村恭男, 渡邊一郎, 永嶋孝一, 園田和正, 古川力丈, 佐々木直子, 高橋啓子, 大久保公恵, 中井俊子, 平山篤志, 中原志朗, 高柳寛
  • Journal Title: 心電図 Volume: 34 Pages: 5055-5067
  • Peer Reviewed
• [Journal Article] 高脂肪食がブタ心房筋の電気的，構造的リモデリングに及ぼす影響 (2014)
  • Author(s): 奥村恭男，渡邊一郎，永嶋孝一，真野博明，園田和正，古川力丈， 佐々木直子，高橋啓子，磯一貴，大久保公恵，中井俊子，平山篤志
  • Journal Title: 日本大学医学部総合医学研究所紀要 Volume: 2 Pages: 66-69
• [Presentation] Effects of a High-Fat Diet on Electrical Properties of Porcine Atria (2015)
  • Author(s): Naoko Sasaki, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Kazumasa Sonoda, Rikitake Kogawa, Keiko Takahashi, Kazuki Iso, Kimie Ohkubo, Toshiko Nakai, Rie Takahashi, Yoshiki Taniguchi, Masako Mitsumata, Mizuki Nikaido, Atsushi Hirayama
  • Organizer: Heart Rhythm 2015, 36th annual scientific sessions
  • Place of Presentation: Boston （USA）
  • Year and Date: 2015-05-13 – 2015-05-16
• [Presentation] Anatomical Proximity Between the Ganglionated Plexi and Epicardial Adipose Tissue: Implication for 3 Dimensional Reconstructed Epicardial Adipose Tissue-guided Ablation (2015)
  • Author(s): Keiko Takahashi, Yasuo Okumura, Ichiro Watanabe, Masayoshi Kofune, Koichi Nagashima, Kazumasa Sonoda, Hiroaki Mano, Kimie Ohkubo, Toshiko Nakai, Naoko Sasaki, Rikitake Kogawa, Mizuki Nikaido, Atsushi Hirayama
  • Organizer: Heart Rhythm 2015, 36th annual scientific sessions
  • Place of Presentation: Boston （USA）
  • Year and Date: 2015-05-13 – 2015-05-16
• [Presentation] Effects of a High-Fat Diet on Electrical Properties of Porcine Atria (2015)
  • Author(s): Naoko Sasaki, Yasuo Okumura, Ichiro Watanabe, Koichi Nagashima, Kazumasa Sonoda, Rikitake Kogawa, Keiko Takahashi, Kazuki Iso, Kimie Ohkubo, Toshiko Nakai, Rie Takahashi, Yoshiki Taniguchi, Masako Mitsumata, Mizuki Nikaido, Atsushi Hirayama
  • Organizer: 第79回日本循環器学会学術集会
  • Place of Presentation: グランフロント大阪会場（大阪府・大阪市）
  • Year and Date: 2015-04-24
• [Presentation] Anatomical Proximity Between the Ganglionated Plexi and Epicardial Adipose Tissue: Implication for 3 Dimensional Reconstructed Epicardial Adipose Tissue-guided Ablation (2014)
  • Author(s): 高橋啓子、奥村恭男、渡邊一郎、永嶋孝一、 園田和正、古川力丈、佐々木直子、磯一貴、大久保公恵、中井俊子、平山篤志
  • Organizer: 第78回日本循環器学会学術集会
  • Place of Presentation: 東京
• [Presentation] 心房細動維持における心房周囲脂肪の役割：心房周囲脂肪の三次元CT構築画ガイド下カテーテルアブレーションの有用性 (2013)
  • Author(s): 奥村恭男、渡邊一郎、永嶋孝一、園田和正、古川力丈、佐々木直子、高橋啓子、磯一貴、大久保公恵、中井俊子、中原志朗、高柳寛、平山篤志
  • Organizer: 第61回日本心臓病学会学術集会
  • Place of Presentation: 熊本
• [Book] 日常診療における心房細動治療Up to Date（Medical Practice 2014年10月号） (2014)
  • Author(s): 里見和浩 編、奥村恭男、永嶋孝一
  • Total Pages: 162
  • Publisher: 文光堂