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Investigation of physiological role of cardiac BKCa channel and its practical application for medical treatment

Research Project

Project/Area Number 25860629
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Cardiovascular medicine
Research InstitutionNational Defense Medical College

Principal Investigator

YADA Hirotaka  防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, その他部局等, 講師 (60338051)

Co-Investigator(Kenkyū-buntansha) ADACHI Takeshi  防衛医科大学校, 循環器内科, 教授 (50231931)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
KeywordsBKCa / カルシウム / BKCaチャネル
Outline of Final Research Achievements

BKCa channel is a unique K channel that activated by calcium and other various conditions. BKCa channel exits mainly in brain and arterioles. BKCa channel expression of cardiac cell membrane is small. However, myocardial mitochondria has BKCa channel and it protects cardiac myocytes via regulation of mitochondrial function. We assessed aorta, cardiac function, electrocardiaogram and electrophysilogical study of BKCa knock out (KO) mouse.
Organ chamber assessment, ultrasonography of heart, electrogram and electrophysiological study showed no significant differences between WT mice and KO mice.
We have to reexamine these parameters in TAC (Transverse Aortic Constriction) mouse model and other heart failure mouse models such as drug overload in the future.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (1 results)

All 2014

All Journal Article (1 results) (of which Peer Reviewed: 1 results)

  • [Journal Article] Suppresion of Rad leads to arrhythmogenesis via PKA-mediated phosphorylation of ryanodine receptor activity in the heart2014

    • Author(s)
      Yamakawa H, Murata M, Suzuki T, Yada H, ishida H, Aizawa Y, Adachi T, Kamiya K, Fukuda K.
    • Journal Title

      Biochemical and Biophysiological Research Communications

      Volume: 452 Pages: 701-707

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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