Early Detection of Myocardial Damage with Cardiac Magnetic Resonance Imaging in Patients with Extracardic Sarcoidosis

• Project/Area Number: 25860630
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Cardiovascular medicine
• Research Institution: National Cardiovascular Center Research Institute
• Principal Investigator: NAGAI Toshiyuki 独立行政法人国立循環器病研究センター, 病院, 医師 (00528218)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 心臓サルコイドーシス / 早期診断 / 多面的アプローチ

Outline of Final Research Achievements

Approximately 13% of extracardiac sarcoidosis patients without cardiac manifestation had myocardial damage defined by late gadollinuum enhancement cardiac magnetic resonance imaging (LGE-CMR), however, this small myocardial damage might not be associated with worse clinical outcomes (Chest 2014; 146: 1064). Futhermore, in additional retrospective analyses, the long-term effect of corticosteroid therapy (Circ J 2015, in press) and the prognostic significance of basal interventricular thinning (Circ J 2015, in press) have also been clarified. These findings will provide the key data for establishment of diagnostic and treatment guidelines in patients with sarcoidosis.

Research Products

• [Journal Article] Effect of Corticosteroid Therapy on Long-term Prognosis in Patients with Cardiac Sarcoidosis (2015)
  • Author(s): Nagai T, Nagano N, Sugano Y, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Ogawa H, Anzai T
  • Journal Title: Circulation Journal Volume: in press
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Association between Basal Thinning of Interventricular Septum and Adverse Long-term Clinical Outcomes in Patients with Cardiac Sarcoidosis (2015)
  • Author(s): Nagano N, Nagai T (equal contributor to first author), Sugano Y, Asaumi Y, Aiba T, Kanzaki H, Kusano K, Noguchi T, Yasuda S, Ogawa H, Anzai T
  • Journal Title: Circulation Journal Volume: in press
  • NAID: 130005083942
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Incidence and Prognostic Significance of Myocardial Late Gadolinium Enhancement in Sarcoidosis Patients without Cardiac Manifestation (2014)
  • Author(s): Nagai T, Kohsaka S, Okuda S, Anzai T, Asano K, Fukuda K.
  • Journal Title: Chest Volume: 146 Pages: 1064-1072
  • Peer Reviewed / Acknowledgement Compliant
• [Journal Article] Incidence and Prognostic Significance of Myocardial Late Gadolinium-Enhancement in Sarcoidosis Patients without Cardiac Manifestation (2014)
  • Author(s): Toshiyuki Nagai, et al
  • Journal Title: Chest Volume: **
  • Peer Reviewed
• [Presentation] Long-term effect of corticosteroid therapy in patients with cardiac sarcoidosis (2014)
  • Author(s): Toshiyuki Nagai, Nobutaka Nagano, Yasuo Sugano, Takeshi Aiba, Hideaki Kanzaki, Kengo Kusano, Masaharu Ishihara, Satoshi Yasuda, Hisao Ogawa, and Toshihisa Anzai
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcelona Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Long-term prognostic impact of basal thinning of the interventricular septum in patients with cardiac sarcoidosis (2014)
  • Author(s): Nobutaka Nagano, Toshiyuki Nagai, Yasuo Sugano, Yoshiaki Morita, Takeshi Aiba, Kengo Kusano, Masaharu Ishihara, Satoshi Yasuda, Hisao Ogawa, and Toshihisa Anzai
  • Organizer: European Society of Cardiology Congress 2014
  • Place of Presentation: Barcelona Spain
  • Year and Date: 2014-08-30 – 2014-09-03
• [Presentation] Long-term effect of corticosteroid therapy in patients with cardiac sarcoidosis
  • Author(s): Toshiyuki Nagai, et al
  • Organizer: European Society of Cardiology, Congress 2014
  • Place of Presentation: Barcelona, Spain
• [Presentation] Long-term prognostic impact of basal thinning of the interventricular septum in patients with cardiac sarcoidosis
  • Author(s): Nobutaka Nagano, Toshiyuki Nagai, et al
  • Organizer: European Society of Cardiology, Congress 2014
  • Place of Presentation: Barcelona, Spain