Elucidating molecular mechanism of thrombin signaling involved in pathogenesis and progression of pulmonary hypertension
| Project/Area Number |
25860632
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Cardiovascular medicine
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| Research Institution | 独立行政法人国立病院機構岡山医療センター(臨床研究部) |
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Principal Investigator |
OGAWA Aiko 独立行政法人国立病院機構岡山医療センター(臨床研究部, その他部局等, その他 (40572748)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | 肺高血圧 / 平滑筋細胞 / トロンビン / 細胞内カルシウム / シグナル伝達 |
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| Outline of Final Research Achievements |
To elucidate the role of thrombin signaling in pathogenesis and progression of pulmonary hypertension, we performed the present study by using lung tissues and isolated pulmonary arterial smooth muscle cells from patients with pulmonary hypertension. Protease activated receptor 1 (PAR1), which acts as a thrombin receptor, was highly expressed in pulmonary arterial smooth muscle cells from patients with pulmonary hypertension. We demonstrated that thrombin/PAR1 signaling and its downstream pathways (Akt/mTOR signaling and p38 signaling) play important roles in progression of pulmonary vascular remodeling. These results indicate that thrombin and its downstream signaling pathways may be novel therapeutic targets in pulmonary hypertension.
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Report
(3 results)
Research Products
(29 results)
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[Journal Article] Different sizes of centrilobular ground-glass opacities in chest high-resolution computed tomography of patients with pulmonary veno-occlusive disease and patients with pulmonary capillary hemangiomatosis2013
Author(s)
Miura A, Akagi S, Nakamura K, Ohta-Ogo K, Hashimoto K, Nagase S, Kohno K, Kusano K, Ogawa A, Matsubara H, Toyooka S, Oto T, Ohtsuka A, Ohe T, Ito H
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Journal Title
Cardiovasc Pathol
Volume: 22
Issue: 4
Pages: 287-293
DOI
Related Report
Peer Reviewed
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[Journal Article] Prostaglandin I(2) induces apoptosis via upregulation of Fas ligand in pulmonary artery smooth muscle cells from patients with idiopathic pulmonary arterial hypertension2011
Author(s)
Akagi S, Nakamura K, Matsubara H, Fukushima Kusano K, Kataoka N, Oto T, Miyaji K, Miura A, Ogawa A, Yoshida M, Ueda-Ishibashi H, Yutani C, Ito H
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Journal Title
Int J Cardiol
Volume: in press
Issue: 3
Pages: 499-505
DOI
Related Report
Peer Reviewed
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