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Study of a new biomarker in pleural mesothelioma and clinical application to early diagnosis

Research Project

Project/Area Number 25860637
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionNiigata University

Principal Investigator

OKAJIMA Masaaki  新潟大学, 医歯学総合病院, 助教 (10463994)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsfibulin-3 / 胸膜中皮腫 / SMRP / 腫瘍マーカー
Outline of Final Research Achievements

Fibulin-3 concentration in plasma and pleural effusion is expected as a new biomarker very high accuracy in the diagnosis of pleural mesothelioma. Our study fibulin-3, have similar reliability in Japanese diagnosis, it is an object to verify can be used in therapy evaluation.
Analyte accumulation of this study was approved by the applicant as a clinical trial at the Niigata University Medical and Dental Hospital. Pleural mesothelioma, as patients with such lung, blood, performs sampling of pleural effusion specimen, to obtain a 113 sample in accordance with the up to now. Mesothelioma patient save serum in the in addition to our department be added fibulin-3 as well as the SMRP, was carried out the analysis, such as CYFRA-21. Society announced during the year, are scheduled to paper reduction.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2016 2015 2013

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 2 results) Presentation (2 results)

  • [Journal Article] Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors.2016

    • Author(s)
      Ko Sato, Satoshi Watanabe,corresponding author Aya Ohtsubo, Satoshi Shoji, Daisuke Ishikawa, Tomohiro Tanaka, Koichiro Nozaki, Rie Kondo, Masaaki Okajima, Satoru Miura, Junta Tanaka, Takuro Sakagami, Toshiyuki Koya, Hiroshi Kagamu, Hirohisa Yoshizawa, and Ichiei Narita
    • Journal Title

      BMC Cancer

      Volume: 16(1) Issue: 1 Pages: 222-222

    • DOI

      10.1186/s12885-016-2271-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy.2015

    • Author(s)
      Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, Igarashi N, Kondo R, Okajima M, Koshio J, Ichikawa K, Nozaki K, Ishikawa D, Koya T, Miura S, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I
    • Journal Title

      Journal of immunology

      Volume: 195(2) Issue: 2 Pages: 726-735

    • DOI

      10.4049/jimmunol.1401468

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Advanced Thymic Cancer Treated with Carboplatin and Paclitaxel in a Patient Undergoing Hemodialysis2015

    • Author(s)
      Miura S, Kagamu H, Sakai T, Nozaki K, Asakawa K, Moro H, Okajima M, Watanabe S, Yamamoto S, Iino N, Goto S, Kazama JJ, Yoshizawa H, Narita I.
    • Journal Title

      Internal Medicine

      Volume: 54 Issue: 1 Pages: 55-58

    • DOI

      10.2169/internalmedicine.54.3484

    • NAID

      130004902998

    • ISSN
      0918-2918, 1349-7235
    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells2013

    • Author(s)
      Koshio, J. Kagamu, H. Nozaki, K. Saida, Y. Tanaka, T. Shoji, S. Igarashi, N. Miura, S. Okajima, M. Watanabe, S. Yoshizawa, H. Narita, I.
    • Journal Title

      Cancer Immunol Immunother

      Volume: 62 Issue: 10 Pages: 1619-28

    • DOI

      10.1007/s00262-013-1467-x

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] The efficacy of triplet antiemetic therapy with 0.75 mg of palonosetron for chemotherapy-induced nausea and vomiting in lung cancer patients receiving highly emetogenic chemotherapy.2013

    • Author(s)
      Miura S, Watanabe S, Sato K, Makino M, Kobayashi O, Miyao H, Iwashima A, Okajima M, Tanaka J, Tanaka H, Kagamu H, Yokoyama A, Narita I, Yoshizawa H.
    • Journal Title

      Support Care Cancer

      Volume: 21 Issue: 9 Pages: 2575-2581

    • DOI

      10.1007/s00520-013-1835-2

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 化学療法が奏効した進行期二相性肺芽腫の1例2013

    • Author(s)
      岡島正明、佐藤昂、才田優、三浦理、渡部聡、田中純太、各務博、吉澤弘久、成田一衛
    • Organizer
      第54回日本肺癌学会総会
    • Place of Presentation
      東京都
    • Related Report
      2013 Research-status Report
  • [Presentation] 集学的治療が奏効した頭頸部原発小細胞癌4例の検討2013

    • Author(s)
      久津間貴和子、岡島正明 、三浦理、渡部聡、田中純太、各務博、吉澤弘久、成田一衛、松山洋、高橋姿
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      宮城県
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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