Study of a new biomarker in pleural mesothelioma and clinical application to early diagnosis

• Project/Area Number: 25860637
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Niigata University
• Principal Investigator: OKAJIMA Masaaki 新潟大学, 医歯学総合病院, 助教 (10463994)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: fibulin-3 / 胸膜中皮腫 / SMRP / 腫瘍マーカー

Outline of Final Research Achievements

Fibulin-3 concentration in plasma and pleural effusion is expected as a new biomarker very high accuracy in the diagnosis of pleural mesothelioma. Our study fibulin-3, have similar reliability in Japanese diagnosis, it is an object to verify can be used in therapy evaluation.
Analyte accumulation of this study was approved by the applicant as a clinical trial at the Niigata University Medical and Dental Hospital. Pleural mesothelioma, as patients with such lung, blood, performs sampling of pleural effusion specimen, to obtain a 113 sample in accordance with the up to now. Mesothelioma patient save serum in the in addition to our department be added fibulin-3 as well as the SMRP, was carried out the analysis, such as CYFRA-21. Society announced during the year, are scheduled to paper reduction.

Research Products

• [Journal Article] Nephrotoxicity of cisplatin combination chemotherapy in thoracic malignancy patients with CKD risk factors. (2016)
  • Author(s): Ko Sato, Satoshi Watanabe,corresponding author Aya Ohtsubo, Satoshi Shoji, Daisuke Ishikawa, Tomohiro Tanaka, Koichiro Nozaki, Rie Kondo, Masaaki Okajima, Satoru Miura, Junta Tanaka, Takuro Sakagami, Toshiyuki Koya, Hiroshi Kagamu, Hirohisa Yoshizawa, and Ichiei Narita
  • Journal Title: BMC Cancer Volume: 16(1) Issue: 1 Pages: 222-222
  • DOI: 10.1186/s12885-016-2271-8
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Critical Roles of Chemoresistant Effector and Regulatory T Cells in Antitumor Immunity after Lymphodepleting Chemotherapy. (2015)
  • Author(s): Saida Y, Watanabe S, Tanaka T, Baba J, Sato K, Shoji S, Igarashi N, Kondo R, Okajima M, Koshio J, Ichikawa K, Nozaki K, Ishikawa D, Koya T, Miura S, Tanaka J, Kagamu H, Yoshizawa H, Nakata K, Narita I
  • Journal Title: Journal of immunology Volume: 195(2) Issue: 2 Pages: 726-735
  • DOI: 10.4049/jimmunol.1401468
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Advanced Thymic Cancer Treated with Carboplatin and Paclitaxel in a Patient Undergoing Hemodialysis (2015)
  • Author(s): Miura S, Kagamu H, Sakai T, Nozaki K, Asakawa K, Moro H, Okajima M, Watanabe S, Yamamoto S, Iino N, Goto S, Kazama JJ, Yoshizawa H, Narita I.
  • Journal Title: Internal Medicine Volume: 54 Issue: 1 Pages: 55-58
  • DOI: 10.2169/internalmedicine.54.3484
  • NAID: 130004902998
  • ISSN: 0918-2918, 1349-7235
  • Peer Reviewed / Open Access
• [Journal Article] DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 3, X-linked is an immunogenic target of cancer stem cells (2013)
  • Author(s): Koshio, J. Kagamu, H. Nozaki, K. Saida, Y. Tanaka, T. Shoji, S. Igarashi, N. Miura, S. Okajima, M. Watanabe, S. Yoshizawa, H. Narita, I.
  • Journal Title: Cancer Immunol Immunother Volume: 62 Issue: 10 Pages: 1619-28
  • DOI: 10.1007/s00262-013-1467-x
  • Peer Reviewed
• [Journal Article] The efficacy of triplet antiemetic therapy with 0.75 mg of palonosetron for chemotherapy-induced nausea and vomiting in lung cancer patients receiving highly emetogenic chemotherapy. (2013)
  • Author(s): Miura S, Watanabe S, Sato K, Makino M, Kobayashi O, Miyao H, Iwashima A, Okajima M, Tanaka J, Tanaka H, Kagamu H, Yokoyama A, Narita I, Yoshizawa H.
  • Journal Title: Support Care Cancer Volume: 21 Issue: 9 Pages: 2575-2581
  • DOI: 10.1007/s00520-013-1835-2
  • Peer Reviewed
• [Presentation] 化学療法が奏効した進行期二相性肺芽腫の1例 (2013)
  • Author(s): 岡島正明、佐藤昂、才田優、三浦理、渡部聡、田中純太、各務博、吉澤弘久、成田一衛
  • Organizer: 第54回日本肺癌学会総会
  • Place of Presentation: 東京都
• [Presentation] 集学的治療が奏効した頭頸部原発小細胞癌4例の検討 (2013)
  • Author(s): 久津間貴和子、岡島正明 、三浦理、渡部聡、田中純太、各務博、吉澤弘久、成田一衛、松山洋、高橋姿
  • Organizer: 第11回日本臨床腫瘍学会学術集会
  • Place of Presentation: 宮城県