| Project/Area Number |
25860639
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Respiratory organ internal medicine
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| Research Institution | Kanazawa University |
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Principal Investigator |
WASEDA Yuko 金沢大学, 医学系, 協力研究員 (80536037)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 病態機序解明 / 閉塞性細気管支炎 / c-kit / イマチニブ |
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| Outline of Final Research Achievements |
Tracheal allografts developed epithelial injury and complete luminal occlusion by day 28, whereas isografts showed intact epithelium without relation of c-Kit. Notably, the administration of imatinib, from day 0 of transplantation, to mice recipients of allografts significantly reduced the tracheal luminal occlusion. In addition, in tracheal allografts, the number of fibrocytes increased significantly between days 3 and 7 of transplantation as compared with isografts, and this recipient-derived fibrocyte infiltration was inhibited by imatinib. Analysis of fibrocyte populations in bone marrow and peripheral blood revealed the same trend, with significant lower number of fibrocytes in the allograft recipients treated with imatinib. Furthermore, in vitro studies showed that imatinib inhibited the differentiation of cultured blood derived monocytes into fibrocytes.
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