| Project/Area Number |
25860642
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Respiratory organ internal medicine
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
TANIZAWA Kiminobu 京都大学, 医学(系)研究科(研究院), 助教 (20639140)
|
|---|
| Project Period (FY) |
2013-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Keywords | 臨床呼吸器学 / 特発性肺線維症 / マイクロRNA / 急性増悪 |
|---|
| Outline of Final Research Achievements |
(1)The long-term prognosis of interstitial lung disease with anti-aminoacyl tRNA synthetase (ARS) antibodies (ARS-ILD), whether having myositis or not, was significantly better that that of idiopathic pulmonary fibrosis (IPF) without anti-ARS antibodies.
(2)Comprehensive microarray analyses of gene expressions in lung tissues and bronchoalveolar lavage fluids (BALFs) from patients with IPF and ARS-ILD revealed that the genes associated with cellular proliferation and those with T-lymphocytes were up-regulated in BALFs from IPF and ARS-ILD patients, respectively.
(3)In acute exacerbations of idiopathic interstitial pneumonia including IPF, the asymmetrical distribution of ground-glass attenuation and/or consolidation was a significant predictor of better outcome.
|
