Micro-RNA in acute exacerbations of idiopathic pulmonary fibrosis

• Project/Area Number: 25860642
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Kyoto University
• Principal Investigator: TANIZAWA Kiminobu 京都大学, 医学(系)研究科(研究院), 助教 (20639140)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: 臨床呼吸器学 / 特発性肺線維症 / マイクロRNA / 急性増悪

Outline of Final Research Achievements

(1)The long-term prognosis of interstitial lung disease with anti-aminoacyl tRNA synthetase (ARS) antibodies (ARS-ILD), whether having myositis or not, was significantly better that that of idiopathic pulmonary fibrosis (IPF) without anti-ARS antibodies.
(2)Comprehensive microarray analyses of gene expressions in lung tissues and bronchoalveolar lavage fluids (BALFs) from patients with IPF and ARS-ILD revealed that the genes associated with cellular proliferation and those with T-lymphocytes were up-regulated in BALFs from IPF and ARS-ILD patients, respectively.
(3)In acute exacerbations of idiopathic interstitial pneumonia including IPF, the asymmetrical distribution of ground-glass attenuation and/or consolidation was a significant predictor of better outcome.

Research Products

• [Journal Article] A toll-like receptor 3 single nucleotide polymorphism in Japanese patients with sarcoidosis. (2015)
  • Author(s): Ikezoe K, Handa T, Tanizawa K, Kubo T, Ito I, Sokai A, Nakatsuka Y, Nagai S, Izumi T, Mishima M
  • Journal Title: Tissue Antigens Volume: 85 Issue: 3 Pages: 204-208
  • DOI: 10.1111/tan.12535
  • Peer Reviewed / Open Access
• [Journal Article] Neutrophil gelatinase-associated lipocalin in idiopathic pulmonary fibrosis. (2014)
  • Author(s): Ikezoe K, Handa T, Mori K, Watanabe K, Tanizawa K, Aihara K, Tsuruyama T, Miyagawa-Hayashino A, Sokai A, Kubo T, Muro S, Nagai S, Hirai T, Chin K, Mishima M
  • Journal Title: Eur Respir J Volume: 43 Issue: 6 Pages: 1807-1809
  • DOI: 10.1183/09031936.00192613
  • Peer Reviewed
• [Journal Article] Total lesion glycolysis as an IgG4-related disease activity marker (2014)
  • Author(s): Nakatsuka Y, Handa T, Nakamoto Y, Nobashi T, Yoshihuji H, Tanizawa K, Ikezoe K, Sokai A, Kubo T, Hirai T, Chin K, Togashi K, Mimori T, Mishima M.
  • Journal Title: Mod Rheumatol. Volume: Ahead of print
  • Peer Reviewed
• [Journal Article] Clinical relevance of plasma prostaglandin F2α metabolite concentrations in patients with idiopathic pulmonary fibrosis (2013)
  • Author(s): Aihara K, Handa T, Oga T, Watanabe K, Tanizawa K, Ikezoe K, Taguchi Y, Sato H, Chin K, Nagai S, Narumiya S, Wells AU, Mishima M.
  • Journal Title: PLoS One. Volume: 8 Issue: 6 Pages: e66017-e66017
  • DOI: 10.1371/journal.pone.0066017
  • NAID: 120005298243
  • Peer Reviewed
• [Presentation] 特発性肺線維症における体重減少の意義についての検討 (2015)
  • Author(s): 中塚賀也, 半田知宏, 谷澤公伸, 祖開暁彦, 池添浩平, 渡邉創, 相原顕作, 久保武, 田口善夫, 平井豊博, 長井苑子, 陳和夫, 三嶋理晃
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京、日本
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] 特発性肺線維症におけるマトリックスメタロプロテイナーゼのバイオマーカーとしての有用性の検討 (2015)
  • Author(s): 祖開暁彦, 半田知宏, 谷澤公伸, 小賀徹, 宇野賀津子, 池添浩平, 中塚賀也, 平井豊博, 長井苑子, 陳和夫, 三嶋理晃
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京、日本
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] 間質性肺炎に対する脳死片肺移植後残存肺の換気/血流の経時変化 (2015)
  • Author(s): 祖開暁彦, 半田知宏, 陳豊史, 谷澤公伸, 志熊啓, 大畑惠資, 久保武, 池添浩平, 中塚賀也, 小熊毅, 平井豊博, 長井苑子, 陳和夫, 伊達洋至, 三嶋理晃
  • Organizer: 第55回日本呼吸器学会学術講演会
  • Place of Presentation: 東京、日本
  • Year and Date: 2015-04-17 – 2015-04-19
• [Presentation] 抗アミノアシルtRNA合成酵素抗体陽性間質性肺炎の長期予後 (2015)
  • Author(s): 谷澤公伸，半田知宏，中嶋蘭，細野祐司, 田口善夫，八田和大, 長井苑子，陳和夫，三森経世, 三嶋理晃
  • Organizer: 第112回日本内科学会学術講演会
  • Place of Presentation: 京都、日本
  • Year and Date: 2015-04-10 – 2015-04-12
• [Presentation] 特発性肺線維症患者における血清尿酸値の検討 (2015)
  • Author(s): 池添浩平，半田知宏，谷澤公伸，祖開暁彦，中塚賀也，久保武，田口善夫，長井苑子，陳和夫，三嶋理晃
  • Organizer: 第112回日本内科学会学術講演会
  • Place of Presentation: 京都、日本
  • Year and Date: 2015-04-10 – 2015-04-12
• [Presentation] Prognostic significance of asymmetrical distribution in acute exacerbation of interstitial pneumonia (2014)
  • Author(s): Akihiko Sokai, Kiminobu Tanizawa, Tomohiro Handa, Takeshi Kubo, Kohei Ikezoe, Yoshinari Nakatsuka, Kensaku Aihara4, Sonoko Nagai5, Toyohiro Hirai1, Kazuo Chin2, Michiaki Mishima1
  • Organizer: European Respiratory Society 2014
  • Place of Presentation: ミュンヘン、ドイツ
  • Year and Date: 2014-09-06 – 2014-09-10
• [Presentation] Serum prostaglandin F2α metabolite concentration in interstitial lung disease associated with (2014)
  • Author(s): Yoshinari Nakatsuka, Tomohiro Handa, Ran Nakashima, Takeshi Kubo, Yuji Hosono2, Akihiko Sokai, Kohei Ikezoe, Yoshio Taguchi, Kazuhiro Hatta, Kiminobu Tanizawa, Toru Oga, Kazuo Chin, Sonoko Nagai, Tsuneyo Mimori, Michiaki Mishima
  • Organizer: American Thoracic Society 2014
  • Place of Presentation: サンディエゴ、米国
  • Year and Date: 2014-05-16 – 2014-05-21
• [Presentation] Serum prostaglandin F2α metabolite concentration in patients with polymyositis/ dermatomyositis associated interstitial lung disease (2014)
  • Author(s): 中塚賀也，半田知宏，祖開暁彦，池添浩平，平井豊博，三嶋理晃，谷澤公伸，小賀 徹，陳和夫，細野裕司，中嶋蘭，三森経世，久保武，田口善夫，八田和大
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪、日本
  • Year and Date: 2014-04-25 – 2014-04-27