Clinical application of granuloma formation modifying factor in sarcoidosis

• Project/Area Number: 25860650
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Oita University
• Principal Investigator: TAKENAKA Ryuichi 大分大学, 医学部, 助教 (90457606)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: サルコイドーシス / HMGB1 / 肉芽腫 / RAGE / 肉牙腫 / ＨＭＧＢ１

Outline of Final Research Achievements

The HMGB1 BALF concentrations of were significantly higher in patients with sarcoidosis (n=72) compared with healthy volunteers (n=15). We could not find significant difference in the serum levels of HMGB1 between sarcoidosis and healthy volunteers. Immunohistochemistry showed HMGB1-positive staining in lymphocytes around the granuloma, macrophage, and alveolar epithelial type II cells of the lung specimen from patient with sarcoidosis obtained by video-assisted thoracoscopic surgery lung biopsy. The increased levels of HMGB1 may play some roles in the pathogenesis of sarcoidosis. Further study is in progress to clarify the detailed roles of HMGB1 in sarcoidosis.