Drug sensitivity of lung cancers harboring novel or rare EGFR mutations

• Project/Area Number: 25860656
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Keio University
• Principal Investigator: YASUDA Hiroyuki 慶應義塾大学, 医学部, 助教 (70365261)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 肺癌 / EGFR遺伝子 / 薬剤感受性

Outline of Final Research Achievements

Lung cancer is a leading cause of cancer related death in Japan. EGFR is one of the most common driver oncogenes in non-small cell lung cancer. The most common EGFR mutations, exon 19 deletion and L858R, account for about 80-90% of EGFR mutations in non-small cell lung cancer. For these classic EGFR mutations, sensitivity to EGFR tyrosine kinase inhibitors are well studied. However, for other relatively rare EGFR mutations, the sensitivity to EGFR tyrosine kinase inhibitors have not been clarified. I this project, we focused on EGFR exon 20 insertion mutations. We clarified the sensitivity of multiple EGFR exon 20 insertion mutations to EGFR tyrosine kinase inhibitors.

Research Products

• [Journal Article] Multiple roles of extracellular fibroblast growth factors in lung cancer cells (2015)
  • Author(s): Suzuki T, Yasuda H, Funaishi K, Arai D, Ishioka K, Ohgino K, Tani T, Hamamoto J, Ohashi A, Naoki K, Betsuyaku T, Soejima K
  • Journal Title: Int J Oncol Volume: 46 Issue: 1 Pages: 423-429
  • DOI: 10.3892/ijo.2014.2718
  • Peer Reviewed / Open Access
• [Journal Article] Structural, biochemical, and clinical characterization of epidermal growth factor receptor (EGFR) exon 20 insertion mutations in lung cancer (2013)
  • Author(s): Yasuda H, Park E, Yun CH, Sng NJ, Lucena-Araujo AR, Yeo WL, Huberman MS, Cohen DW, Nakayama S, Ishioka K, Yamaguchi N, Hanna M, Oxnard GR, Lathan CS, Moran T, Sequist LV, Chaft JE, Riely GJ, Arcila ME, Soo RA, Meyerson M, Eck MJ, Kobayashi SS, Costa DB
  • Journal Title: Ｓｃｉｅｎｃｅ Ｔｒａｎｓｌａｔｉｏｎａｌ Ｍｅｄｉｃｉｎｅ Volume: 18;5(216) Issue: 216 Pages: 1-10
  • DOI: 10.1126/scitranslmed.3007205
  • Peer Reviewed
• [Presentation] Clinical, structural and biochemical characterization of EGFR exon 20 insertion mutations in non-small-cell lung cancer (NSCLC). (2014)
  • Author(s): Hiroyuki Yasuda, Kenzo Soejima, Kota Ishioka, Katsuhiko Naoki, Tomoko Betsuyaku, Susumu Kobayashi, Daniel B. Costa.
  • Organizer: 第54回日本呼吸器学会総会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-26