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Development of new biomarker of interstitial pneumonia and drug-induced lung disease

Research Project

Project/Area Number 25860663
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Respiratory organ internal medicine
Research InstitutionKurume University

Principal Investigator

MASAKI Okamoto  久留米大学, 医学部, 講師 (50352133)

Co-Investigator(Kenkyū-buntansha) HOSHINO Tomoaki  久留米大学, 内科学講座呼吸器・神経・膠原病内科部門, 主任教授 (00261066)
Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywordsぺリオスチン / 間質性肺炎 / バイオマーカー / 特発性肺線維症 / 特発性間質性肺炎 / 血清バイオマーカー / ペリオスチン
Outline of Final Research Achievements

Proposal: Development of new biomarker of interstitial lung disease and drug-induced lung disease.
Result: We showed that periostin as extracellular matrix protein was new serum biomarker of interstitial lung disease.Specifically, we showed that serum periostin level had high sensitivity and specificity as a diagnostic biomarker using ROC analysis. Moreover, we showed that periostin was predictor of decline of pulmonary function and survival by statistical analysis.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (10 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 1 results,  Open Access: 1 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis.2015

    • Author(s)
      Tajiri M, Okamoto M, et al.
    • Journal Title

      The Respiratory Investigation

      Volume: 53 Pages: 73-81

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 特集「間質性肺炎とアレルギー」 各論 特発性間質性肺炎とサイトカイン2014

    • Author(s)
      岡元 昌樹、星野 友昭
    • Journal Title

      アレルギーの臨床

      Volume: 33 Pages: 17-22

    • Related Report
      2013 Research-status Report
  • [Journal Article] The progression of comorbidity in IL-18 transgenic chronic obstructive pulmonary disease mice model.2014

    • Author(s)
      Takenaka S, Kawayama T, Imaoka H, Sakazakia Y, Oda H, Kaku Y, MatsuokaM, Okamoto M, Kato S, Yamada K, Hoshino T.
    • Journal Title

      BBRC

      Volume: 445 Pages: 597-601

    • Related Report
      2013 Research-status Report
  • [Journal Article] Interleukin-18 expression, CD8+ T cells, and eosinophils in lungs of nonsmokers with fatal asthma.2014

    • Author(s)
      Oda H, Kawayama T, Imaoka H, Sakazaki Y, Kaku Y, Okamoto M, Kitasato Y, Edakuni N, Takenaka S, Yoshida M, Iwanaga T, Kato S, O'Byrne PM, Hoshino T.
    • Journal Title

      Asthma Immunol

      Volume: 112 Pages: 23-28

    • Related Report
      2013 Research-status Report
  • [Journal Article] IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13.2013

    • Author(s)
      Sawada M, Kawayama T, Imaoka H, Sakazaki Y, Oda H, Takenaka S, Kaku Y, Azuma K, Tajiri, M, Edakuni N, Okamoto M, Kato S, Hoshino T.
    • Journal Title

      PLos One

      Volume: 8

    • Related Report
      2013 Research-status Report
  • [Presentation] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis.2014

    • Author(s)
      Tajiri M, Okamoto M, et al.
    • Organizer
      European Respiratory Society Annual Congress
    • Place of Presentation
      Munich, Germany
    • Year and Date
      2014-09-06 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] 細胞外マトリックス蛋白;ペリオスチンの特発性肺線維症のバイオマーカーとしての解析2014

    • Author(s)
      岡元  昌樹, 他
    • Organizer
      日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Year and Date
      2014-04-25 – 2014-04-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] 特発性肺線維症の新規血清バイオマーカーの解析2014

    • Author(s)
      岡元 昌樹, 他
    • Organizer
      日本内科学会講演会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-11 – 2014-04-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 特発性肺線維症の新規血清バイオマーカーの解析2014

    • Author(s)
      岡元 昌樹、藤本 公則、上甲 剛、田尻 守拡、小野 純也、太田 昭一郎、出原 賢治、星野 友昭
    • Organizer
      第111回日本内科学会講演会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
  • [Presentation] 血清ペリオスチン値は、IPFの長期予後因子である2014

    • Author(s)
      岡元 昌樹,藤本 公則, 上甲  剛,田尻 守拡, 小野 純也, 太田 昭一郎,出原 賢治,星野 友昭
    • Organizer
      第54回日本呼吸器学会学術講演会
    • Place of Presentation
      大阪
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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