Development of new biomarker of interstitial pneumonia and drug-induced lung disease

• Project/Area Number: 25860663
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Respiratory organ internal medicine
• Research Institution: Kurume University
• Principal Investigator: MASAKI Okamoto 久留米大学, 医学部, 講師 (50352133)
• Co-Investigator(Kenkyū-buntansha): HOSHINO Tomoaki 久留米大学, 内科学講座呼吸器・神経・膠原病内科部門, 主任教授 (00261066)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: ぺリオスチン / 間質性肺炎 / バイオマーカー / 特発性肺線維症 / 特発性間質性肺炎 / 血清バイオマーカー / ペリオスチン

Outline of Final Research Achievements

Proposal: Development of new biomarker of interstitial lung disease and drug-induced lung disease.
Result: We showed that periostin as extracellular matrix protein was new serum biomarker of interstitial lung disease.Specifically, we showed that serum periostin level had high sensitivity and specificity as a diagnostic biomarker using ROC analysis. Moreover, we showed that periostin was predictor of decline of pulmonary function and survival by statistical analysis.

Research Products

• [Journal Article] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis. (2015)
  • Author(s): Tajiri M, Okamoto M, et al.
  • Journal Title: The Respiratory Investigation Volume: 53 Pages: 73-81
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 特集「間質性肺炎とアレルギー」 各論 特発性間質性肺炎とサイトカイン (2014)
  • Author(s): 岡元 昌樹、星野 友昭
  • Journal Title: アレルギーの臨床 Volume: 33 Pages: 17-22
• [Journal Article] The progression of comorbidity in IL-18 transgenic chronic obstructive pulmonary disease mice model. (2014)
  • Author(s): Takenaka S, Kawayama T, Imaoka H, Sakazakia Y, Oda H, Kaku Y, MatsuokaM, Okamoto M, Kato S, Yamada K, Hoshino T.
  • Journal Title: BBRC Volume: 445 Pages: 597-601
• [Journal Article] Interleukin-18 expression, CD8+ T cells, and eosinophils in lungs of nonsmokers with fatal asthma. (2014)
  • Author(s): Oda H, Kawayama T, Imaoka H, Sakazaki Y, Kaku Y, Okamoto M, Kitasato Y, Edakuni N, Takenaka S, Yoshida M, Iwanaga T, Kato S, O'Byrne PM, Hoshino T.
  • Journal Title: Asthma Immunol Volume: 112 Pages: 23-28
• [Journal Article] IL-18 induces airway hyperresponsiveness and pulmonary inflammation via CD4+ T cell and IL-13. (2013)
  • Author(s): Sawada M, Kawayama T, Imaoka H, Sakazaki Y, Oda H, Takenaka S, Kaku Y, Azuma K, Tajiri, M, Edakuni N, Okamoto M, Kato S, Hoshino T.
  • Journal Title: PLos One Volume: 8
• [Presentation] Serum level of periostin can predict long-term outcome of idiopathic pulmonary fibrosis. (2014)
  • Author(s): Tajiri M, Okamoto M, et al.
  • Organizer: European Respiratory Society Annual Congress
  • Place of Presentation: Munich, Germany
  • Year and Date: 2014-09-06 – 2014-09-10
• [Presentation] 細胞外マトリックス蛋白；ペリオスチンの特発性肺線維症のバイオマーカーとしての解析 (2014)
  • Author(s): 岡元 昌樹, 他
  • Organizer: 日本呼吸器学会学術講演会
  • Place of Presentation: 大阪
  • Year and Date: 2014-04-25 – 2014-04-27
• [Presentation] 特発性肺線維症の新規血清バイオマーカーの解析 (2014)
  • Author(s): 岡元 昌樹, 他
  • Organizer: 日本内科学会講演会
  • Place of Presentation: 東京
  • Year and Date: 2014-04-11 – 2014-04-13
• [Presentation] 特発性肺線維症の新規血清バイオマーカーの解析 (2014)
  • Author(s): 岡元 昌樹、藤本 公則、上甲 剛、田尻 守拡、小野 純也、太田 昭一郎、出原 賢治、星野 友昭
  • Organizer: 第111回日本内科学会講演会
  • Place of Presentation: 東京
• [Presentation] 血清ペリオスチン値は、IPFの長期予後因子である (2014)
  • Author(s): 岡元 昌樹，藤本 公則, 上甲 剛，田尻 守拡, 小野 純也, 太田 昭一郎，出原 賢治，星野 友昭
  • Organizer: 第54回日本呼吸器学会学術講演会
  • Place of Presentation: 大阪