| Project/Area Number |
25860666
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Hirosaki University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
IMAIZUMI Tadaatsu 弘前大学, 大学院医学研究科, 教授 (90232602)
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| Research Collaborator |
NARITA Ikuyo
FUKUSHI Yasuyo
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 糸球体上皮細胞 / CD80 / ポドサイト / ネフローゼ症候群 |
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| Outline of Final Research Achievements |
In minimal change disease (MCD), T cell-disorder hypothesis has been proposed, but has not been proved. CD80 is one of the co-stimulatory molecules which helps T cell activation. Recently, the increased expression of CD80 in the podocytes and in the urine was demonstrated in MCD. We hypothesized that the disorder of the regulatory mechanism of CD80 could be the cause of MCD. Therefore, we used cultured podocytes and investigated the expressions of the interleukin-10 and cytotoxic T-lymphocyte-associated protein 4 which usually regulate CD80.
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