The relationship between homeostatic inflammation and renin-angiotensin system in the progression of diabetic nephropathy
Project/Area Number |
25860673
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Kumamoto University (2014) Kyoto University (2013) |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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Keywords | 自然炎症 / 糖尿病性腎症 / レニン・アンジオテンシン系 / MRP8 / 細胞間クロストーク |
Outline of Final Research Achievements |
We have previously observed that the macrophages (Mf) infiltrated in glomeruli showed higher MRP8 positivity compared to those in interstitium in diabetic nehropathy. TLR4 deletion did not ameliorate the worsening of diabetic nephropathy nor glomerular MRP8 upregulation by angiotensin II infusion. Besides, MRP8 upregulation in Mf stimulated with mesangilal cell-cultured medium was not altered by TLR4 antagonist. Taken together, MRP8 could become a novel therapeutic target rather than blockade of TLR4 especially in the pathogenesis associated with intraglomerular cross talk.
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Report
(3 results)
Research Products
(18 results)
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[Journal Article] An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions.2015
Author(s)
Kanda J, Mori K, Kawabata H, Kuwabara T, Mori KP, Imamaki H, Kasahara M, Yokoi H, Mizumoto C, Thoennissen NH, Koeffler HP, Barasch J, Takaori-Kondo A, Mukoyama M, Nakao K.
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Journal Title
Clin Exp Nephrol.
Volume: 19
Issue: 1
Pages: 99-106
DOI
NAID
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Journal Article] Predictive significance of kidney myeloid-related protein 8 expression in patients with obesity- or type 2 diabetes-associated kidney diseases2014
Author(s)
Kuwabara T, Mori K, Kasahara M, Yokoi H, Imamaki H, Ishii A, Koga K, Sugawara A, Yasuno S, Ueshima K, Morikawa T, Konishi Y, Imanishi M, Nishiyama A, Nakao K, Mukoyama M
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Journal Title
PloS One
Volume: 9
Issue: 2
Pages: e88942-e88942
DOI
Related Report
Peer Reviewed / Open Access
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[Journal Article] Macrophage-mediated glucolipotoxicity via myeloid-related protein 8/toll-like receptor 4 signaling in diabetic nephropathy2014
Author(s)
Kuwabara, T., Mori, K., Mukoyama, M., Kasahara, M., Yokoi, H., Nakao, K.
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Journal Title
Clinical and Experimental Nephrology
Volume: impress
Issue: 4
Pages: 584-592
DOI
NAID
Related Report
Peer Reviewed
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[Journal Article] An AKI biomarker lipocalin 2 in the blood derives from the kidney in renal injury but from neutrophils in normal and infected conditions.2014
Author(s)
Kanda J, Mori K, Kawabata H, Kuwabara T, Mori KP, Imamaki H, Kasahara M, Yokoi H, Mizumoto C, Thoennissen NH, Koeffler HP, Barasch J, Takaori-Kondo A, Mukoyama M, Nakao K.
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Journal Title
Clin Exp Nephrol
Volume: in press
NAID
Related Report
Peer Reviewed
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[Presentation] Glomerular MRP8 expression predicts progression of proteinuria in obese or type 2 diabetic patients.2014
Author(s)
Takashige Kuwabara, Kiyoshi Mori, Hideki Yokoi, Shinji Yasuno, Masato Kasahara, Kenji Ueshima, Kazuwa Nakao, Masahito Imanishi, Akira Nishiyama, Motoko Yanagita, Masashi Mukoyama
Organizer
Annual Meeting of the American Society of Nephrology
Place of Presentation
Philadelaphia, USA
Year and Date
2014-11-15
Related Report
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[Presentation] Macrophage-mediated glucolipotoxicity via MRP8/TLR4 signaling in diabetic nephropathy
Author(s)
Takashige Kuwabara, Kiyoshi Mori, Masashi Mukoyama, Masato Kasahara, Hideki Yokoi, Hirotaka Imamaki, Akira Ishii, Kenichi Koga, Keita P Mori, Yukiko Kato, Akira Sugawara, Kazuwa Nakao
Organizer
Kidney and Lipids, World Congress of Nephrology, Satellite Synposium
Place of Presentation
Fukuoka, Japan
Related Report
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