The development of differentiation method that human induced pluripotency stem cells differentiate into mature renal cells as clinical applications.
| Project/Area Number |
25860675
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Okayama University (2014)
Kyoto University (2013) |
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Principal Investigator |
INOUE Tatsuyuki 岡山大学, 医歯(薬)学総合研究科, 助教 (60598564)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | iPS細胞 / 腎前駆細胞 |
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| Outline of Final Research Achievements |
We aimed to develop a method for differentiating hiPSCs (induced pluripotency stem cells) into mature renal cells. It became necessary to prepare a renal progenitor cells in large scale and stable, we had to change the aim to the development of efficient method that iPSCs differentiated into renal progenitor cells. We performed high-throughput screening of chemical compounds and identified several compounds. In second screening, we identified 3 compounds as hit compounds. These compounds had a dose-dependency, and affected the mouse embryonic kidney. We are going to analyze the function of these compounds in developing kidney, and also establish the highly efficient differentiation method.
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Report
(3 results)
Research Products
(2 results)
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[Presentation] Development of differentiation methods from human iPSCs/ESCs into nephron progenitor cells.2013
Author(s)
Toyohara T, Yamagishi Y, Mae S, Inoue T, Araoka T, Kasahara T, Yamanaka S, Nakajima H, Osafune K.
Organizer
11th Annual Meeting, International Society for Stem Cell Research.
Place of Presentation
Boston Convention and Exhibition Center, Boston, MA, USA.
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