| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
|
|---|
| Outline of Final Research Achievements |
We have reported that both autophagy and apoptosis were related to the pathogenesis in acute kidney injury (AKI). However, the roles of autophagy and mitophagy in the pathogenesis of renal disease are poorly understood. Because proximal tubules highly include mitochondria, the tubules that could prevent apoptosis by autophagy and mitophagy might be possibly related to dedifferentiation and regeneration. We reported that sestrin, p53-related gene, which induced by ischemia-repurfusion in proximal tubules, suppressed apoptosis and further progressed autophagy in AKI model using GFP-LC3-TG mice that could recognize autophagy in vivo.
|
