The role of mitochondrial function and mitophagy in the pathogenesis of acute kidney injury
| Project/Area Number |
25860683
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Kochi University |
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Principal Investigator |
Oode Kazu 高知大学, 医学部附属病院, 医員 (40589537)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | 急性腎障害 / 尿細管障害 / オートファジー / マイトファジー / オート－ファジー |
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| Outline of Final Research Achievements |
We have reported that both autophagy and apoptosis were related to the pathogenesis in acute kidney injury (AKI). However, the roles of autophagy and mitophagy in the pathogenesis of renal disease are poorly understood. Because proximal tubules highly include mitochondria, the tubules that could prevent apoptosis by autophagy and mitophagy might be possibly related to dedifferentiation and regeneration. We reported that sestrin, p53-related gene, which induced by ischemia-repurfusion in proximal tubules, suppressed apoptosis and further progressed autophagy in AKI model using GFP-LC3-TG mice that could recognize autophagy in vivo.
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Report
(4 results)
Research Products
(22 results)
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[Journal Article] Sestrin-2 and BNIP3 regulate autophagy and mitophagy in renal tubular cells in acute kidney injury2013
Author(s)
Ishihara M, Urushido M, Hamada K, Matsumoto T, Shimamura Y, Ogata K, Inoue K, Taniguchi Y, Horino T, Fujieda M, Terada Y
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Journal Title
Am J Physiol Renal Physiol
Volume: 305(4)
Issue: 4
Pages: 495-509
DOI
Related Report
Peer Reviewed
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[Presentation] PNUTS(Phosphatase 1 Nuclear-Targeting Subunit)Is Down-Regulated in Acute Kideny Injury and Aging,and Regulates Cell Cycle,Fibrosis,DNA Damage of Renal Tubular Cells： A Longitudinal Follow-Up Study.2015
Author(s)
Yuki Osakabe，Tatsuki Matsumoto, Kazu Hamada-Ode, Yoshiko Shimamura, Koji Ogata, Kosuke Inoue, Yoshinori Taniguchi, Taro Horino, Shimpei Fujimoto，Yoshio Terada
Organizer
The 48th Annual Meeting of American Society of Nephrology
Place of Presentation
San Diego Convention Center(San Diego, USA)
Year and Date
2015-11-03
Related Report
Int'l Joint Research
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