| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
|---|
| Outline of Final Research Achievements |
The DNA damage response is important for genome stability and cell survival. Recently, it has been reported that association between DNA damage response and aging and arteriosclerosis. These DNA damage are may play a role of process of aging associated disease. We found that phosphorylation of histone H2AX, one of the sensitive marker of DNA double strand breaks, is increased in fibrosis region in mouse model. Furthermore, Histone H2AX knockout mice significantly reduced fibrosis region after UUO. These findings suggested that the histone H2AX activation may have potential role of pro-fibrotic pathways.
|
