The Effects of DNA Damage Response on Renal Fibrosis
Project/Area Number |
25860684
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Kidney internal medicine
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Research Institution | Osaka City University |
Principal Investigator |
KIZU Akane 大阪市立大学, 医学(系)研究科(研究院), 助教 (30623201)
|
Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
|
Keywords | 線維化 / DNA損傷 / DNA修復 / 腎線維化 |
Outline of Final Research Achievements |
The DNA damage response is important for genome stability and cell survival. Recently, it has been reported that association between DNA damage response and aging and arteriosclerosis. These DNA damage are may play a role of process of aging associated disease. We found that phosphorylation of histone H2AX, one of the sensitive marker of DNA double strand breaks, is increased in fibrosis region in mouse model. Furthermore, Histone H2AX knockout mice significantly reduced fibrosis region after UUO. These findings suggested that the histone H2AX activation may have potential role of pro-fibrotic pathways.
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Report
(3 results)
Research Products
(4 results)
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[Patent(Industrial Property Rights)] 加熱装置2015
Inventor(s)
森田隆、吉田佳世、木津あかね
Industrial Property Rights Holder
森田隆、吉田佳世、木津あかね
Industrial Property Rights Type
特許
Industrial Property Number
2015-069853
Filing Date
2015-03-30
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