Epigenetic regulation of podocyte phenotype through KLF4
| Project/Area Number |
25860687
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | Keio University |
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Principal Investigator |
Hayashi Kaori 慶應義塾大学, 医学部, 助教 (60445294)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | 慢性腎臓病 / 蛋白尿 / ポドサイト / エピゲノム / 尿蛋白 / KLF4 / エピジェネテイック / エピジェネティックス |
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| Outline of Final Research Achievements |
We have shown that transcription factor Kruppel-like factor 4 (KLF4) modulates podocyte epigenome and attenuates proteinuria（Hayashi, et al. J Clin Invest. 2014). Moreover, we demonstrated that renin-angiotensin system (RAS) blockade reset podocyte epigenome through KLF4 in part（Hayashi, et al. Kidney Int. 2015). These results provide a new concept that RAS blockade can exert therapeutic effects through epigenetic modulation of the kidney gene expression, and suggest a novel therapeutic approach for treatment of proteinuric kidney diseases.
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Report
(4 results)
Research Products
(13 results)
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[Journal Article] Renal arteriolar injury by salt intake causes ‘Salt Memory’ for the development of hypertension.2014
Author(s)
Hideyo Oguchi, Hiroyuki Sasamura, Kazunobu Shinoda, Shinya Morita, Hidaka Kono, Ken Nakagawa, Kimiko Ishiguro, Kaori Hayashi, Mari Nakamura, Tatsuhiko Azegami, Mototsugu Oya, Hiroshi Itoh.
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Journal Title
Hypertension
Volume: 64(4)
Issue: 4
Pages: 784-791
DOI
Related Report
Peer Reviewed / Open Access
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