Development of the tailor-made medicine for IgA nephropathy by using the single nucleotide peptide of the Toll-like receptor 9 gene

• Project/Area Number: 25860689
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Kidney internal medicine
• Research Institution: Juntendo University
• Principal Investigator: SATO Daisuke 順天堂大学, 医学部, 助教 (50621942)
• Co-Investigator(Renkei-kenkyūsha): MATSUZAKI Keiichi 京都大学, 健康科学センター, 助教 (20709315)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
• Keywords: IgA腎症 / TLR9 / 塩基多型 / オーダーメイド治療

Outline of Final Research Achievements

We conducted the retrospective cohort study to clarify the association between decline of renal function and the pattern of single nucleotide polymorphism (SNP) in IgA nephropathy (IgAN). We enrolled 111 IgAN patients who diagnosed from 2004 to 2009.
We collected baseline characters and determined SNP (TT, CT, CC). Although the baseline characteristics of patients were not significantly different in each group, decline of renal function in patients with TT-SNP was faster than patients with CT/CC SNP in multivariate model. Present results suggested that TT-SNP can be a prognostic factor in IgAN.

Research Products

• [Journal Article] Diagnosis and activity assessment of immunoglobulin A nephropathy: current perspectives on noninvasive testing with aberrantly glycosylated immunoglobulin A-related biomarkers (2014)
  • Author(s): Suzuki Y, Suzuki H, Makita Y, Takahata A, Takahashi K, Muto M, Sasaki Y, Kelimu A, Matsuzaki K, Yanagawa H, Okazaki K, Tomino Y
  • Journal Title: Int J Nephrol Renovasc Dis Volume: 7 Pages: 409-414
  • DOI: 10.2147/ijnrd.s50513
  • Peer Reviewed / Open Access
• [Journal Article] Changes in Nephritogenic Serum Galactose-Deficient IgA1 in IgA Nephropathy following Tonsillectomy and Steroid Therapy. (2014)
  • Author(s): Nakata J, Suzuki Y, Suzuki H, Sato D, Kano T, Yanagawa H, Matsuzaki K, Horikoshi S, Novak J, Tomino Y.
  • Journal Title: PLoS One Volume: 21 Issue: 2 Pages: e89707-e89707
  • DOI: 10.1371/journal.pone.0089707
  • Peer Reviewed / Open Access
• [Presentation] Usefulness of remission criteria as surrogate endpoint in the progression of IgA nephropathy (2015)
  • Author(s): Matsuzaki K, Suzuki Y, Suzuki H, Shimizu Y, Ohsawa I, Horikoshi S, Tomino Y
  • Organizer: World Congress of Nephrology 2015
  • Place of Presentation: Cape Town, South Africa
  • Year and Date: 2015-03-16