| Project/Area Number |
25860695
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Kidney internal medicine
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| Research Institution | University of Occupational and Environmental Health, Japan |
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Principal Investigator |
MIYAMOTO Tetsu 産業医科大学, 医学部, 非常勤医師 (30611305)
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| Co-Investigator(Kenkyū-buntansha) |
OTSUJI Yutaka 産業医科大学, 教授 (30264427)
TAMURA Masahito 産業医科大学病院腎センター, 診療教授 (40330980)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
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| Keywords | ペントラキシン３ / 栄養リスク / 血液透析 / バイオマーカー / 低栄養 |
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| Outline of Final Research Achievements |
In this multicenter prospective cohort study comprising 380 maintenance hemodialysis patients, we investigated the effect of plasma PTX3 levels on all-cause mortality, with a particular focus on nutritional risk. In patients in the high nutritional risk group (GNRI<91.2), a significant correlation was evident between high PTX3 levels (> 6.29 ng/mL)and mortality risk. Plasma PTX3 levels may be a useful biomarker for assessing mortality risk in Japanese hemodialysis patients, especially those with high nutritional risk. Concurrent measurement of other inflammatory markers such as CRP and IL-6 is expected to improve the predictive power of PTX3. Furthermore, the association between CRP and nutritional risk calculated on the basis of GNRI depends on albumin levels, yet PTX3 had a strong association with anthropometric parameters.
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