Analysis of mitochondrial regulation by DJ-1
Project/Area Number |
25860697
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Hokkaido University |
Principal Investigator |
NIKI Kazuko 北海道大学, 薬学研究科(研究院), 助教 (50447645)
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Project Period (FY) |
2013-04-01 – 2016-03-31
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Project Status |
Completed (Fiscal Year 2015)
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Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
|
Keywords | DJ-1 / PARK7 / パーキンソン病 / プロテアーゼ |
Outline of Final Research Achievements |
Secreted DJ-1 from astrocytes protected co-cultured neurons against oxidative stress, while the DJ-1 mutants discovered in PARK7 did not. DJ-1 directly interacts with Beclin and this binding was promoted by oxidation of DJ-1. There are different views on the function of DJ-1 in autophagy. Then, I investigated whether DJ-1 promote or suppress autophagy, and then it became clear that DJ-1 promotes autophagy. We identified KIF1B as target substrate for DJ-1 protease. It is possible that DJ-1 regulate mitochondrial transport through cleavage of KIF1B.
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Report
(4 results)
Research Products
(14 results)
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[Journal Article] Deficiency of spermatogenesis and reduced expression of spermatogenesis-related genes in prefoldin 5-mutant mice.2015
Author(s)
Yamane, T., Shimizu, T., Takahashi-Niki, K., Takekoshi, Y., Iguchi-Ariga, S.M.M. and Ariga, H.
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Journal Title
Biochem. Biophys. Rep.
Volume: 1
Pages: 33-51
Related Report
Peer Reviewed
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[Journal Article] Immunostaining of oxidized DJ-1 in human and mouse brains.2014
Author(s)
Saito Y, Miyasaka T, Hatsuta H, Takahashi-Niki K, Hayashi K, Mita Y, Kusano-Arai O, Iwanari H, Ariga H, Hamakubo T, Yoshida Y, Niki E, Murayama S, Ihara Y, Noguchi N.
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Journal Title
J Neuropathol Exp Neurol.
Volume: 73
Pages: 714-28
Related Report
Peer Reviewed
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