| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Outline of Final Research Achievements |
Secreted DJ-1 from astrocytes protected co-cultured neurons against oxidative stress, while the DJ-1 mutants discovered in PARK7 did not. DJ-1 directly interacts with Beclin and this binding was promoted by oxidation of DJ-1. There are different views on the function of DJ-1 in autophagy. Then, I investigated whether DJ-1 promote or suppress autophagy, and then it became clear that DJ-1 promotes autophagy. We identified KIF1B as target substrate for DJ-1 protease. It is possible that DJ-1 regulate mitochondrial transport through cleavage of KIF1B.
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