Searching for the immune target molecules in chronic inflammatory demyelinating polyneuropathy by proteomic analysis.

• Project/Area Number: 25860699
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Chiba University
• Principal Investigator: BEPPU MINAKO 千葉大学, 医学(系)研究科(研究院), 助教 (70623669)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: 慢性炎症性脱髄性多発神経炎 / プロテオーム解析 / 自己抗体

Outline of Final Research Achievements

Chronic inflammatory demyelinating polyneuropathy (CIDP) is classified into several clinical subtypes such as “typical” and “atypical” CIDP, and the pathogenetic mechanisms are presumably different among the subtypes . Several CIDP-specific autoantibodies have been reported, whereas they are detected only in a small population of CIDP patients. The aim of this study was to identify novel immunological target molecules of CIDP using an unbiased proteomics-based screening approach. In this study, We identified several candidate proteins. Further examination of the role of these proteins in the pathogenesis of CIDP is required.

Research Products

• [Journal Article] Serum cytokine and chemokine profiles in patients with chronic inflammatory demyelinating polyneuropathy. (2015)
  • Author(s): Beppu M, Sawai S, Misawa S, Sogawa K, Mori M, Ishige T, Satoh M, Nomura F, Kuwabara S
  • Journal Title: Journal of Neuroimmunology Volume: 279 Pages: 7-10
  • DOI: 10.1016/j.jneuroim.2014.12.017
  • Peer Reviewed
• [Journal Article] Bortezomib-induced neuropathy: axonal membrane depolarization precedes development of neuropathy (2014)
  • Author(s): Nasu S, Misawa S, Nakaseko C, Shibuya K, Isose S, Sekiguchi Y, Mitsuma, Ohmori S, Iwai Y, Beppu M, Shimizu N, Ohwada C, Takeda Y, Fujimaki Y, Kuwabara S S,
  • Journal Title: Clinical Neurophysiology Volume: 125 Issue: 2 Pages: 381-387
  • DOI: 10.1016/j.clinph.2013.07.014
  • Peer Reviewed
• [Journal Article] Prominent fatigue in spinal muscular atrophy and spinal and bulbar muscular atrophy: evidence of activity-dependent conduction block. (2013)
  • Author(s): Noto Y, Misawa S, Mori M, Kawaguchi N, Kanai K, Shibuya K, Isose S, Nasu S, Sekiguchi Y, Beppu M, Ohmori S, Nakagawa M, Kuwabara S.
  • Journal Title: Clin Neurophysiol. Volume: 124(9) Issue: 9 Pages: 1893-8
  • DOI: 10.1016/j.clinph.2012.12.053
  • Peer Reviewed
• [Journal Article] Patterns of sensory nerve conduction abnormalities in Fisher syndrome : more predominant involvement of group Ia afferents than skin afferents (2013)
  • Author(s): Sekiguchi Y, Misawa S, Shibuya K, Mitsuma S, Hirano S, Ohmori S, Koga S, Iwai Y, Beppu M, Kuwabara S
  • Journal Title: Clin Neurophysiol Volume: 124(7) Issue: 7 Pages: 1465-9
  • DOI: 10.1016/j.clinph.2013.01.020
  • Peer Reviewed
• [Journal Article] Split hand syndrome in amyotrophic lateral sclerosis: different excitability changes in the thenar and hypothenar motor axons (2013)
  • Author(s): Shibuya K
  • Journal Title: J Neurol Neurosurg Psychiatry Volume: 印刷中 Issue: 9 Pages: 969-72
  • DOI: 10.1136/jnnp-2012-304109
  • Peer Reviewed
• [Journal Article] Ambiguous effects of anti-VEGF monoclonal antibody (bevacizumab) for POEMS syndrome. (2013)
  • Author(s): Sekiguchi Y, Misawa S, Shibuya K, Nasu S, Mitsuma S, Iwai Y, Beppu M, Sawai S, Ito S, Hirano S, Nakaseko C, Kuwabara S.
  • Journal Title: Journal of Neurology, Neurosurgery and Psychiatry Volume: 84 Issue: 12 Pages: 1346-1348
  • DOI: 10.1136/jnnp-2012-304874
  • Peer Reviewed
• [Presentation] 小児発症の慢性炎症性脱髄性多発神経炎の臨床・電気生理学的特徴 (2014)
  • Author(s): 別府美奈子 .三澤園子 藤井克則 澤井摂 渋谷和幹 関口縁 三津間さつき 岩井雄太 渡辺慶介 磯瀬沙希里 大森茂樹 網野寛 桑原聡
  • Organizer: 第44回日本臨床神経生理学会学術大会
  • Place of Presentation: 福岡国際会議場（福岡県福岡市）
  • Year and Date: 2014-11-19 – 2014-11-21
• [Presentation] Serum cytokine profiles of chronic inflammatory demyellinating polyneuropathy. (2013)
  • Author(s): Beppu M, Sawai S, Misawa S, Sogawa K, Ishige T, Satoh M, Mori M, Nomura F, Kuwabara S
  • Organizer: World congress of neurolgy
  • Place of Presentation: Vienna, Austria
• [Presentation] プロテオーム解析を用いた脱髄型ギラン・バレー症候群の免疫標的分子の探索． (2013)
  • Author(s): 澤井 摂, 佐藤守, 森雅裕, 三澤園子, 風見隆浩, 別府美奈子, 関口縁, 野村文夫, 桑原聡
  • Organizer: 第54回日本神経学会
  • Place of Presentation: 東京
• [Presentation] 遺伝性神経筋疾患の発症前診断に対する遺伝カウンセリング (2013)
  • Author(s): 別府美奈子, 澤井摂, 宇津野恵美, 西村基, 松下一之, 羽田明, 桑原聡, 野村文夫
  • Organizer: 第54回日本神経学会
  • Place of Presentation: 東京