Molecular Mechanism of Myelination Regulated by Teneurin-4
Project/Area Number |
25860701
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Neurology
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Research Institution | Tokyo Medical and Dental University |
Principal Investigator |
Suzuki Nobuharu 東京医科歯科大学, 大学院保健衛生学研究科, 准教授 (30596565)
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Research Collaborator |
YAMADA YOSHIHIKO 米国国立保健衛生研究所, 歯学頭蓋研究所, 部長
HIRASAWA ERI 順天堂大学, 大学院医学研究科・老人性疾患病態治療研究センター, 教授
AKAZAWA CHIHIRO 東京医科歯科大学, 大学院保健衛生学研究科, 教授
MABUCHI YO 東京医科歯科大学, 大学院保健衛生学研究科, 助教
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Project Period (FY) |
2013-04-01 – 2017-03-31
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Project Status |
Completed (Fiscal Year 2016)
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Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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Keywords | オリゴデンドロサイト / 髄鞘 / Teneurin-4 |
Outline of Final Research Achievements |
Myelination by oligodendrocytes is essential for proper functioning of the central nervous system (CNS). Here, we showed that a type II transmembrane protein teneurin-4 (Ten-4) was essential for CNS myelination. Further, Ten-4 possessed cell-cell adhesion activity. The recombinant protein of the Ten-4 extracellular domain promoted cell attachment and a positive effect on oligodendrocyte morphological change and myelination. These findings suggest that Ten-4 is a novel regulator of oligodendrocyte differentiation and that it plays a critical role in the myelination of axons in the CNS.
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Report
(5 results)
Research Products
(18 results)
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[Journal Article] Teneurin-4 promotes cellular protrusion formation and neurite outgrowth through focal adhesion kinase signaling.2014
Author(s)
Suzuki N, Numakawa T, Chou J, de Vega S, Mizuniwa C, Sekimoto K, Adachi N, Kunugi H, Arikawa-Hirasawa E, Yamada Y, Akazawa C.
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Journal Title
FASEB J.
Volume: 28(3)
Issue: 3
Pages: 1386-97
DOI
Related Report
Peer Reviewed
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[Presentation] Teneurin-4 Positively Regulates Neural Cell Process Formation and Synaptogenesis2013
Author(s)
Nobuharu Suzuki, Tadahiro Numakawa, Joshua Chou, Susana de Vega, Chihiro Mizuniwa, Kaori Sekimoto, Naoki Adachi, Hiroshi Kunugi, Eri Arikawa-Hirasawa, Yoshihiko Yamada, and Chihiro Akazawa
Organizer
Neuro 2013、第36回日本神経科学大会
Place of Presentation
国立京都国際会館
Related Report