| Project/Area Number |
25860701
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
Suzuki Nobuharu 東京医科歯科大学, 大学院保健衛生学研究科, 准教授 (30596565)
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| Research Collaborator |
YAMADA YOSHIHIKO 米国国立保健衛生研究所, 歯学頭蓋研究所, 部長
HIRASAWA ERI 順天堂大学, 大学院医学研究科・老人性疾患病態治療研究センター, 教授
AKAZAWA CHIHIRO 東京医科歯科大学, 大学院保健衛生学研究科, 教授
MABUCHI YO 東京医科歯科大学, 大学院保健衛生学研究科, 助教
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | オリゴデンドロサイト / 髄鞘 / Teneurin-4 |
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| Outline of Final Research Achievements |
Myelination by oligodendrocytes is essential for proper functioning of the central nervous system (CNS). Here, we showed that a type II transmembrane protein teneurin-4 (Ten-4) was essential for CNS myelination. Further, Ten-4 possessed cell-cell adhesion activity. The recombinant protein of the Ten-4 extracellular domain promoted cell attachment and a positive effect on oligodendrocyte morphological change and myelination. These findings suggest that Ten-4 is a novel regulator of oligodendrocyte differentiation and that it plays a critical role in the myelination of axons in the CNS.
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