The pathogenesis of GEM bodies reduction in ALS affected tissues.
| Project/Area Number |
25860703
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Niigata University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | ALS / U snRNAs / GEM小体 / スプライシング / TDP-43 / GEM / SMN / snRNAs / GEM body |
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| Outline of Final Research Achievements |
Our object is the elucidation of ALS pathogenesis. We have already found the reduction of minor spliceosomal U snRNA and GEM bodies in ALS affected tissues. U snRNA is main component of the splicing machinery and GEM bodies have important role in the maturation of U snRNAs. We intended to clarify the pathogenesis of GEM bodies reduction and aberrant splicing in ALS affected tissues. In this study, we found the reduction of SMN mRNA in TDP-43 depleted cells. SMN protein is main component of GME bodies. And there were minor spliceosome dependent splicing aberrations in ALS affected tissues.
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Report
(3 results)
Research Products
(9 results)
