| Project/Area Number |
25860704
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Shinshu University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
YOSHIDA Kunihiro 信州大学, 医学部, 特任教授 (90242693)
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| Research Collaborator |
KINOSHITA Michiaki 諏訪赤十字病院, 神経内科, 医師
KONDO Yasufumi 信州大学, 医学部, 助教
MATSUSHIMA Akira 鹿教湯三才山リハビリテーションセンター鹿教湯病院, 神経内科, 医師
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| Project Period (FY) |
2013-04-01 – 2017-03-31
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| Project Status |
Completed (Fiscal Year 2016)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | HDLS / コロニー刺激因子1受容体 / 神経軸索ジストロフィー / マクロファージコロニー刺激因子 / 神経軸索スフェロイドを伴う遺伝性び慢性白質脳症 / 若年性認知症 / マクロファージコロニー刺激因子受容体 / ミクログリア / 白質脳症 / コロニー刺激因子１受容体 / スフェロイド / マクロファージ |
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| Outline of Final Research Achievements |
Hereditary diffuse leukoencephalopathy with spheroids (HDLS) is characterized by early-onset cognitive dysfunction caused by mutations in the colony-stimulating factor 1 receptor (CSF1R ) gene.We performed biochemical examinations on autopsied brains from patients with HDLS. Our results suggests decreased protein expression of CSF1R in HDLS brain. In analysis of peripheral blood mononuclear cells from HDLS patients suggests impaired induction and survival of macrophages under stimulation with CSF-1 and IL-34.
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