In vivo distribution of alfa 7 receptors in the Alzheimaer's disease

• Project/Area Number: 25860707
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Hamamatsu University School of Medicine
• Principal Investigator: TERADA tatsuhiro 浜松医科大学, メディカルフォトニクス研究センター, 助教 (80550178)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000); Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
• Keywords: アルツハイマー病 / α7ニコチン受容体 / [11C]MeQAA-PET / α７アセチルコリン受容体 / PET / [11C]Me-QAA / [11C]MeQAA

Outline of Final Research Achievements

The α4β2 nAChRs are associated with learning and memory functions. Since we have developed a radiotracer for α7 nAChRs [11C]Me-QAA that can apply to humans in a positron emission tomography (PET) study, we here report the distribution of α7 nAChRs in the patients of Alzheimaer’s disease. Simultaneously after venous injection of [11C]Me-QAA, the dynamic scans for 60 minutes was performed. All subjects were evaluated with neuropsychological tests and conventional MRI. [11C]Me-QAA binds more to the cerebral cortex, especially medial and lateral temporal cortices. Age-related and cognitive-related correlations were found in [11C]Me-QAA BPND in the cholinergic projection regions. The appearance of [11C]Me-QAA over the cerebral cortex with dominancy of the limbic region suggests that α7 nAChRs engage more in memory and intellectual cognitive activity.

Research Products

• [Journal Article] The possible link between GABAergic dysfunction and cognitive decline in a patient with idiopathic hypoparathyroidism (2015)
  • Author(s): Tatsuhiro Terada, Akihiro Kakimoto, Etsuji Yoshikawa, Satoshi Kono, Tomoyasu Bunai, Yasushi Hosoi, Makiko Sakao-Suzuki, Takashi Konishi, Hiroaki Miyajima, Yasuomi Ouchi
  • Journal Title: Internal Medicine Volume: in press
  • NAID: 130005097155
  • Peer Reviewed / Acknowledgement Compliant
• [Presentation] 認知機能障害を呈した特発性副甲状腺機能低下症の脳PET所見 (2014)
  • Author(s): 寺田達弘、河野智、武内智康、坂尾万幾子、細井泰志、小西高志、宮嶋裕明、尾内康臣
  • Organizer: 第140回 日本神経学会東海北陸地方会
  • Place of Presentation: 福井
  • Year and Date: 2014-11-01
• [Presentation] Microglial activation and memory impairment in early Parkinson’s disease (2014)
  • Author(s): Tatsuhiro Terada, Masamichi Yokokura, Satoshi Kono, Takashi Konishi, Yasushi Hosoi, Makiko Sakao, Tomoyasu Bunai, Hiroaki Miyajima, Etsuji Yoshikawa, Masami Futatsubashi, Yasuomi Ouchi
  • Organizer: 第37回日本神経科学大会
  • Place of Presentation: 横浜
  • Year and Date: 2014-09-11 – 2014-09-13
• [Presentation] Reduced gray matter correlated with frontal dysfunction in Parkinson's disease (2014)
  • Author(s): 寺田達弘， 小尾智一， 宮田淳， 久保田学， 吉住美穂， 村井俊哉， 杉浦明， 山崎公也,高嶋浩嗣， 坂尾万幾子， 細井泰志， 小西高志， 河野智， 宮嶋裕明， 尾内康臣， 溝口功一
  • Organizer: 第55回日本神経学会学術大会
  • Place of Presentation: 福岡
  • Year and Date: 2014-05-21 – 2014-05-24