| Project/Area Number |
25860707
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Hamamatsu University School of Medicine |
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Principal Investigator |
TERADA tatsuhiro 浜松医科大学, メディカルフォトニクス研究センター, 助教 (80550178)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
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| Keywords | アルツハイマー病 / α7ニコチン受容体 / [11C]MeQAA-PET / α７アセチルコリン受容体 / PET / [11C]Me-QAA / [11C]MeQAA |
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| Outline of Final Research Achievements |
The α4β2 nAChRs are associated with learning and memory functions. Since we have developed a radiotracer for α7 nAChRs [11C]Me-QAA that can apply to humans in a positron emission tomography (PET) study, we here report the distribution of α7 nAChRs in the patients of Alzheimaer’s disease. Simultaneously after venous injection of [11C]Me-QAA, the dynamic scans for 60 minutes was performed. All subjects were evaluated with neuropsychological tests and conventional MRI. [11C]Me-QAA binds more to the cerebral cortex, especially medial and lateral temporal cortices. Age-related and cognitive-related correlations were found in [11C]Me-QAA BPND in the cholinergic projection regions. The appearance of [11C]Me-QAA over the cerebral cortex with dominancy of the limbic region suggests that α7 nAChRs engage more in memory and intellectual cognitive activity.
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