• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Generation of new model mice that reflect human sporadic parkinson's disease

Research Project

Project/Area Number 25860711
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionKyoto University

Principal Investigator

ASANO Takeshi  京都大学, 医学(系)研究科(研究院), 研究員 (40649167)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Keywordsalpha-synuclein / 酸化ストレス / パーキンソン病 / αーシヌクレイン / α-シヌクレイン
Outline of Final Research Achievements

Parkinson’s disese is one of the common neurodegenerative diseases. The complete therapy of Parkinson’s disese has not been established because the pathogenesis of Parkinson’s disese is still unclear. To establish the new mammal models that resembles human Parkinson’s disese, we performed this study. We inter-crossed alpla-synuclein Tg mice with IRP2 Tg mice. The double-Tg mice had a little abnormal motor performance. Andn insoulble alpha-synuclein was obserbed in some regions in the brin of the double Tg mice. These results sugesest that our new mice is useful model for the reserch of Parkinson’s disese.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (9 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (7 results)

  • [Journal Article] Target- and input-dependent organization of AMPA and NMDA receptors in synaptic connections of the cochlear nucleus2015

    • Author(s)
      Rubio ME, Fukazawa Y, Kamasawa N, Clarkson C, Molnar E, Shigemoto R
    • Journal Title

      J Comp Neurol

      Volume: 588 Pages: 29-35

    • DOI

      10.1016/j.neulet.2014.12.052

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant2014

    • Author(s)
      Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
    • Journal Title

      Acta Neuropathol Commun.

      Volume: 2 Issue: 1 Pages: 172-185

    • DOI

      10.1186/s40478-014-0172-0

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Screening of small molecules that down-regulate α-synuclein expression2015

    • Author(s)
      Takeshi Asano
    • Organizer
      Alpha-Synuclein: The Gateway to Parkinsonism
    • Place of Presentation
      Innsbruck
    • Year and Date
      2015-02-11 – 2015-02-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] パーキンソン病の治療に向けたα-シヌクレインの転写を抑制する低分子化合物のスクリーニング2014

    • Author(s)
      浅野 剛史、山門 穂高、高橋 良輔
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] Involvement of iron in the pathogenesis of Parkinson’s disease2014

    • Author(s)
      Takeshi Asano
    • Organizer
      MDS-AOS Basic Scientists Summer School
    • Place of Presentation
      台北
    • Year and Date
      2014-07-13 – 2014-07-15
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスを用いたin vivoにおけるゾニサミドの作用機構2014

    • Author(s)
      浅野 剛史、山門 穂高、高橋 良輔
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する2013

    • Author(s)
      浅野 剛史、松井 秀彰、Robert Gavinio、上村 紀人、伊東 秀文、谷口 善仁、Jie Shen、武田 俊一、植村 健吾、山門 穂高、髙橋 良輔
    • Organizer
      第22回 日本Cell Death学会学術集会
    • Place of Presentation
      京都大学医学部 芝蘭会館
    • Related Report
      2013 Research-status Report
  • [Presentation] マウスを用いたゾニサミドの作用機序の解析2013

    • Author(s)
      浅野 剛史、山門 穂高、髙橋 良輔
    • Organizer
      第7回 パーキンソン病・運動障害疾患コングレス
    • Place of Presentation
      京王プラザホテル
    • Related Report
      2013 Research-status Report
  • [Presentation] PINK1とParkinは脊椎動物において相補的にミトコンドリアを保護する2013

    • Author(s)
      浅野 剛史、松井 秀彰、Robert Gavinio、上村 紀人、伊東 秀文、谷口 善仁、Jie Shen、武田 俊一、植村 健吾、山門 穂高、髙橋 良輔
    • Organizer
      第36回 日本分子生物学会
    • Place of Presentation
      神戸国際展示場
    • Related Report
      2013 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi