Generation of new model mice that reflect human sporadic parkinson's disease
| Project/Area Number |
25860711
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Kyoto University |
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Principal Investigator |
ASANO Takeshi 京都大学, 医学(系)研究科(研究院), 研究員 (40649167)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Keywords | alpha-synuclein / 酸化ストレス / パーキンソン病 / αーシヌクレイン / α-シヌクレイン |
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| Outline of Final Research Achievements |
Parkinson’s disese is one of the common neurodegenerative diseases. The complete therapy of Parkinson’s disese has not been established because the pathogenesis of Parkinson’s disese is still unclear. To establish the new mammal models that resembles human Parkinson’s disese, we performed this study. We inter-crossed alpla-synuclein Tg mice with IRP2 Tg mice. The double-Tg mice had a little abnormal motor performance. Andn insoulble alpha-synuclein was obserbed in some regions in the brin of the double Tg mice. These results sugesest that our new mice is useful model for the reserch of Parkinson’s disese.
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Report
(3 results)
Research Products
(9 results)
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[Journal Article] Immunoreactivity of valosin-containing protein in sporadic amyotrophic lateral sclerosis and in a case of its novel mutant2014
Author(s)
Ayaki T, Ito H, Fukushima H, Inoue T, Kondo T, Ikemoto A, Asano T, Shodai A, Fujita T, Fukui S, Morino H, Nakano S, Kusaka H, Yamashita H, Ihara M, Matsumoto R, Kawamata J, Urushitani M, Kawakami H, Takahashi R.
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Journal Title
Acta Neuropathol Commun.
Volume: 2
Issue: 1
Pages: 172-185
DOI
Related Report
Peer Reviewed / Open Access
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