| Project/Area Number |
25860712
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | Osaka University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 多発性硬化症 / 腸管免疫 / 酵母 / 腸内細菌叢 |
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| Outline of Final Research Achievements |
The intestinal microflora affects the pathogenesis of several autoimmune
diseases by influencing immune system function. We aimed to investigate the effects of various dietary yeasts contained in fermented foods on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).
The effects of eight yeasts selected from 18 types of yeasts contained in fermented foods were examined. Of these, administration of Candida kefyr ameliorated the severity of EAE. Reduced numbers of inflammatory cells, and increased regulatory T cells and dendritic cells were observed. Analysis of microflora of C. kefyr-treated mice demonstrated decreased Bacteroides compared to control flora. Transfer of intestinal microbiota also resulted in decreased Bacteroides and ameliorated symptoms of EAE. Thus, oral administration of C. kefyr ameliorated EAE by altering the microflora. In addition, our findings also suggested the potential health benefits of dietary yeasts.
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