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The effects of dieatry yeasts on experimental autoimmune encephalomyelitis

Research Project

Project/Area Number 25860712
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Neurology
Research InstitutionOsaka University

Principal Investigator

TAKATA Kazushiro  大阪大学, 医学部附属病院, 医員 (20573223)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords多発性硬化症 / 腸管免疫 / 酵母 / 腸内細菌叢
Outline of Final Research Achievements

The intestinal microflora affects the pathogenesis of several autoimmune
diseases by influencing immune system function. We aimed to investigate the effects of various dietary yeasts contained in fermented foods on experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis (MS).
The effects of eight yeasts selected from 18 types of yeasts contained in fermented foods were examined. Of these, administration of Candida kefyr ameliorated the severity of EAE. Reduced numbers of inflammatory cells, and increased regulatory T cells and dendritic cells were observed. Analysis of microflora of C. kefyr-treated mice demonstrated decreased Bacteroides compared to control flora. Transfer of intestinal microbiota also resulted in decreased Bacteroides and ameliorated symptoms of EAE. Thus, oral administration of C. kefyr ameliorated EAE by altering the microflora. In addition, our findings also suggested the potential health benefits of dietary yeasts.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (7 results)

All 2015 2014 2013

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (5 results)

  • [Journal Article] Dietary Yeasts Reduce Inflammation in Central Nerve System via Microflora2015

    • Author(s)
      Takata K, Tomita T, Okuno T, Kinoshita M, Koda T, Honorat JA, Takei M, Hagihara K, Sugimoto T, Mochizuki H, Sakoda S, Nakatsuji Y
    • Journal Title

      Annals of Clinical and Translational Neurology

      Volume: 2 Issue: 1 Pages: 56-66

    • DOI

      10.1002/acn3.153

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 11C-Acetate PET Imaging in Patients with Multiple Sclerosis.2014

    • Author(s)
      Takata K, Kato H, Shimosegawa E, Okuno T, Koda T, Sugimoto T, Mochizuki H, Hatazawa J, Nakatsuji Y.
    • Journal Title

      PLoS One.

      Volume: 9 Issue: 11 Pages: e111598-e111598

    • DOI

      10.1371/journal.pone.0111598

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Intestinal microflora modified by Candida kefyr reduces the susceptibility to experimental autoimmune encephalomyelitis2014

    • Author(s)
      Takata K
    • Organizer
      2014 Joint ACTRIMS-ECTRIMS Meeting
    • Place of Presentation
      Boston, USA
    • Year and Date
      2014-09-10 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食餌成分(酵母)の腸管免疫を介した多発性硬化症病態への関与2014

    • Author(s)
      高田和城、中辻裕司、木下允、奥野龍禎、甲田亨、望月秀樹、佐古田 三郎
    • Organizer
      第26回神経免疫学会
    • Place of Presentation
      金沢市、石川県
    • Year and Date
      2014-09-04 – 2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 食餌成分(酵母)の腸管免疫を介した多発性硬化症病態への影響2014

    • Author(s)
      高田和城、中辻裕司、木下允、奥野龍禎、甲田亨、富田貴之、武井雅也、萩原幸一郎、佐古田 三郎、望月 秀樹
    • Organizer
      第55回日本神経学会学術大会
    • Place of Presentation
      福岡市、福岡県
    • Year and Date
      2014-05-21 – 2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] Dietary Component, As An Environmental Factor, Affects The Development of EAE2013

    • Author(s)
      K. Takata, T. Tomita, T. Koda, T. Okuno, J.A. Honorat, M. Kinoshita, M. Takei, K. Hagihara, S. Sakoda, H. Mochizuki, Y. Nakatsuji
    • Organizer
      PACTRIMS
    • Place of Presentation
      Kyoto, Japan
    • Related Report
      2013 Research-status Report
  • [Presentation] 食品中成分による多発性硬化症モデルの増悪2013

    • Author(s)
      高田 和城、Joseph A Honorat、甲田 亨、多田智、木下 允、奥野 龍禎、中辻 裕司、佐古田 三郎、望月 秀樹
    • Organizer
      日本神経学会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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