|Budget Amount *help
¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
|Outline of Final Research Achievements
Amyotrophic lateral sclerosis (ALS) is a progressive neurodegeneration disease of motor neurons resulting in the atrophy and weakness of muscle. Optineurin (OPTN) is one of genes causing ALS. It is thought that dysfunction and deletion of OPTN develop ALS. Therefore, I produced OPTN knockout mouse and then examined its mice behaviorally and histologically at both the young and the old age. At the results of these experiments, there was no significantly difference between non-genetically modified mice and the OPTN knockout mice. However, the deletion of OPTN prolonged survival in a transgenic mouse model of ALS.