The roles of antibodies against NMDA-type glutamate receptors for the pathogenesis of prion disease
| Project/Area Number |
25860715
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Neurology
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| Research Institution | The University of Tokushima |
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Principal Investigator |
FUJITA Koji 徳島大学, ヘルスバイオサイエンス研究部, 助教 (80601765)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
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| Keywords | プリオン病 / 抗体 / グルタミン酸受容体 |
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| Outline of Final Research Achievements |
This project aimed to test the hypothesis that autoantibodies against NMDA-type glutamate receptors are associated with dysfunction of the receptors in prion disease. I planed to (1) detect the epitope of the antibodies using peptide arrays, (2) evaluate the cells that are associated with the antibody production, and (3) assess the effect of antibodies on NMDA-type glutamate receptors, to clarify the pathomechanisms of neurodegeneration and to contribute to diagnosis and treatment of prion disease.
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Report
(3 results)
Research Products
(4 results)
