The roles of antibodies against NMDA-type glutamate receptors for the pathogenesis of prion disease

Research Project

Project/Area Number	25860715
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Neurology
Research Institution	The University of Tokushima
Principal Investigator	FUJITA Koji 徳島大学, ヘルスバイオサイエンス研究部, 助教 (80601765)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000) Fiscal Year 2013: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Keywords	プリオン病 / 抗体 / グルタミン酸受容体
Outline of Final Research Achievements	This project aimed to test the hypothesis that autoantibodies against NMDA-type glutamate receptors are associated with dysfunction of the receptors in prion disease. I planed to (1) detect the epitope of the antibodies using peptide arrays, (2) evaluate the cells that are associated with the antibody production, and (3) assess the effect of antibodies on NMDA-type glutamate receptors, to clarify the pathomechanisms of neurodegeneration and to contribute to diagnosis and treatment of prion disease.

Report

(3 results)