Analysis of determinant of HAM tropism using HAM tropic HTLV-1

• Project/Area Number: 25860729
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurology
• Research Institution: Kansai Medical University
• Principal Investigator: UENO TAKAHARU 関西医科大学, 医学部, 助教 (80405167)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000); Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
• Keywords: HTLV-1 / HAM

Outline of Final Research Achievements

Adult T cell leukemia (ATL) and HTLV-1 related myelopathy (HAM) are major HTLV-1 related diseases. Though the determinant of the HTLV-1 disease tropism is still unknown, the difference of viral stain is considered to be involved in the tropism. To investigate this hypothesis, we compared the phenotype of ATL tropic Japanese HTLV-1 with that of HAM tropic Jamaican/Iranian (J/I) HTLV-1. The data showed the production of J/I HTLV-1 was more than that of Japanese HTLV-1 and suggested the different expression pattern of viral mRNA might be involved in it.

Research Products

• [Journal Article] An animal model of adult T-cell leukemia: humanized mice with HTLV-1-specific immunity (2014)
  • Author(s): Tezuka K, Xun R, Tei M, Ueno T, Tanaka M, Takenouchi N, Fujisawa J
  • Journal Title: Blood Volume: 123 Issue: 3 Pages: 346-355
  • DOI: 10.1182/blood-2013-06-508861
  • Peer Reviewed
• [Journal Article] Oral administration of an HSP90 inhibitor, 17-DMAG, intervenes tumor-cell infiltration into multiple organs and improves survival period for ATL model mice. (2013)
  • Author(s): Ikebe E, Kawaguchi A, Tezuka K, et al
  • Journal Title: Blood Cancer Journal Volume: 3 Issue: 8 Pages: e132-e132
  • DOI: 10.1038/bcj.2013.30
  • Peer Reviewed
• [Presentation] Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral expression (2013)
  • Author(s): Takaharu Ueno, Runze Xun, Mineki Saito, Kenta Tezuka, Yuetsu Tanaka and Jun-ichi Fujisawa
  • Organizer: 16th International Conference on Human Retrovirology : HTLV and Related Viruses
  • Place of Presentation: Monteal, CANADA
• [Presentation] Carrier model of HTLV-1 infection in humanized NOG mice (2013)
  • Author(s): Kenta Tezuka, Mami Tei, Takaharu Ueno, Runze Xun, Jun-ichi Fujisawa
  • Organizer: 16th International Conference on Human Retrovirology : HTLV and Related Viruses
  • Place of Presentation: Monteal, CANADA
• [Presentation] Inhibition of ATL development in humanized mouse model by AZT/INF treatment (2013)
  • Author(s): Kenta Tezuka, Mami Tei, Takaharu Ueno, Runze Xun, Hidekatu Iha, Jun-ichi Fujisawa
  • Organizer: 16th International Conference on Human Retrovirology : HTLV and Related Viruses
  • Place of Presentation: Monteal, CANADA
• [Presentation] Altered pattern in viral mRNA expression of Iranian type HTLV-1 leading to enhanced viral production
  • Author(s): 荀潤澤、上野孝治、齊藤峰輝、手塚健太、田中勇悦、 藤澤順一
  • Organizer: 第66回日本細菌学会関西支部総会・学術講演会
  • Place of Presentation: 大阪大学 （大阪）