| Project/Area Number |
25860731
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Neurology
|
|---|
| Research Institution | Okinaka Memorial Institute for Medical Research |
|---|
Principal Investigator |
MAEDA MEIKO 公益財団法人冲中記念成人病研究所, その他部局等, 研究員 (20646799)
|
|---|
| Research Collaborator |
Shimizu Jun 東京大学, 附属病院神経内科, 准教授
Uesaka Yoshikazu 国家公務員共済組合連合会, 虎の門病院神経内科, 部長
|
|---|
| Project Period (FY) |
2013-04-01 – 2017-03-31
|
| Project Status |
Completed (Fiscal Year 2016)
|
| Budget Amount *help |
¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2016: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
|
|---|
| Keywords | 筋炎 / 自己抗体 / 心臓合併症 / 呼吸筋合併症 / 抗ミトコンドリア抗体 / 不整脈 / 原発性胆汁性肝硬変 |
|---|
| Outline of Final Research Achievements |
Eighteen AMA-positive myositis patients with cardiac complications (11 females and 7 males) were identified. The ages at onset of symptom ranged from 36 to 70 years (mean, 50.1 ± 9.0 years). Duration between the onsets of symptom to end of follow-up (disease courses) ranged 1.5 to 18.0 years (mean, 9.0 ± 5.2 years). All patients were associated with arrhythmia and had decreased EF ranging 9 to 71 % (mean, 40.2 ± 17.2 %). Ten patients required intervention therapy (catheter ablation, n=7; defibrillator, n=3; pacemaker, n=2; mitral valve surgery, n=1). Four patients died in the follow-up period including two patients who died suddenly. Histopathological analysis revealed that the biopsied specimen of all the patients fulfilled the criteria of non-specific myositis.
|
