| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000)
Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
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| Outline of Final Research Achievements |
We have found that hepatic activation of glucose metabolism by glucokinase overexpression induced reduction in resting heart rate. Hepatic glucokinase-induced afferent vagal signal suppressed the neuronal activity of the rostral raphe pallidus (rRPa), which controls cardiac sympathetic nerve activity. Thus, this liver-to-heart interaction is mediated by a neuronal pathway consisting of hepatic vagal afferent, rRPa and cardiac sympathetic efferent. This neuronal relay may act as a protective mechanism against leptin-induced tachycardia and hypertension.
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