The roles of the autonomic nervous system in the control of energy metabolism

• Project/Area Number: 25860735
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Tohoku University
• Principal Investigator: TSUKITA SOHEI 東北大学, 大学病院, 助教 (30623160)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 肥満 / 自律神経 / エネルギー代謝 / 肝糖代謝 / 褐色脂肪組織 / 心臓 / メタボリックシンドローム / 自律神経系 / 臓器連関

Outline of Final Research Achievements

We have found that hepatic activation of glucose metabolism by glucokinase overexpression induced reduction in resting heart rate. Hepatic glucokinase-induced afferent vagal signal suppressed the neuronal activity of the rostral raphe pallidus (rRPa), which controls cardiac sympathetic nerve activity. Thus, this liver-to-heart interaction is mediated by a neuronal pathway consisting of hepatic vagal afferent, rRPa and cardiac sympathetic efferent. This neuronal relay may act as a protective mechanism against leptin-induced tachycardia and hypertension.

Research Products

• [Journal Article] Rho-Kinase Inhibition Ameliorates Metabolic Disorders through Activation of AMPK Pathway in Mice (2014)
  • Author(s): Noda K, Nakajima S, Godo S, Saito H, Ikeda S, Shimizu T, Enkhjargal B, Fukumoto Y, Tsukita S, Yamada T, Katagiri H, Shimokawa H.
  • Journal Title: PLoS One Volume: 9(11) Issue: 11 Pages: e110446-e110446
  • DOI: 10.1371/journal.pone.0110446
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Simultaneous copy number losses within multiple subtelomeric regions in early-onset type 2 diabetes mellitus (2014)
  • Author(s): Kodama S, Yamada T, Imai J, Sawada S, Takahashi K, Tsukita S, Kaneko K, Uno K, Ishigaki Y, Oka Y, Katagiri H
  • Journal Title: PLoS One Volume: 9(4) Issue: 4 Pages: e88602-e88602
  • DOI: 10.1371/journal.pone.0088602
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] 臓器間神経ネットワークによるエネルギー代謝調節機構 (2014)
  • Author(s): 突田壮平、山田哲也、片桐秀樹
  • Journal Title: 内分泌・糖尿病・代謝内科 Volume: 38(1) Pages: 9-13
  • Peer Reviewed / Open Access / Acknowledgement Compliant