| Project/Area Number |
25860736
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Metabolomics
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| Research Institution | Tohoku University |
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Principal Investigator |
UNO Kenji 東北大学, 大学病院, 助教 (50596632)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
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| Keywords | アミノ酸代謝 / メタボリックシンドローム / 肥満 / mTOR |
|---|
| Outline of Final Research Achievements |
Metabolic processes in different organs are regulated in a coordinated manner via both neuronal signals and humoral factors. We have previously demonstrated that neuronal networks, originating in the liver, play important roles in maintaining glucose and energy homeostasis, by enhancing pancreatic beta cell mass and energy consumption, respectively. Nutrient overloads due to food energy excess affect these metabolic regulations, resulting in progression of obesity and metabolic disorders. In this study, we aim to discover a new mechanism of hepatic amino acid signaling on the development of metabolic syndrome from the point of view of inter-organ network. At this stage, we have identified that hepatic amino acid signaling is involved in the regulation of systemic lipid metabolism.
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