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The novel mechanism of improving insulin resistance by sphingosine 1-phosphate

Research Project

Project/Area Number 25860740
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Metabolomics
Research InstitutionThe University of Tokyo

Principal Investigator

KURANO Makoto  東京大学, 医学部附属病院, 助教 (60621745)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsアポ蛋白M / スフィンゴシン1-リン酸 / インスリン抵抗性 / 糖代謝 / LDL受容体 / インスリン分泌
Outline of Final Research Achievements

In this study, we investigated the involvement of sphingosine 1-phosphate (S1P), a potent bioactive lipid mediator, and apolipoprotein M (apoM), a carrier and modulator of S1P, in the pathogenesis of diabetes. We found with animal experimetns that apoM and S1P exert anti-diabetic properties by improving insulin resistance in liver and promoting insulin secretion from beta-cell. We also observed that both plasma and hepatic contents of apoM and S1P are increased in streptozotocin-induced diabetic mice and mice fed with high fat diet. These results suggest the possibility of applying apoM and S1P into clinical laboratory medicine and therapeutic medicine in the fields of diabetes.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (13 results)

All 2015 2014 2013 Other

All Journal Article (5 results) (of which Peer Reviewed: 5 results,  Open Access: 3 results,  Acknowledgement Compliant: 3 results) Presentation (7 results) (of which Invited: 2 results) Remarks (1 results)

  • [Journal Article] LDL Receptor and ApoE are Involved in the Clearance of ApoM-associated Sphingosine 1-phosphate2015

    • Author(s)
      Kurano M, Tsukamoto K, Hara M, Ohkawa R, Ikeda H, Yatomi Y.
    • Journal Title

      J Biol Chem

      Volume: 290 Issue: 4 Pages: 2477-88

    • DOI

      10.1074/jbc.m114.596445

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modulation of sphingosine-1-phosphate and apolipoprotein M levels in the plasma, liver and kidneys in streptozotocin-induced diabetic mice2014

    • Author(s)
      Nojiri T, Kurano M, Tokuhara Y, Ohkubo S, Hara M, Ikeda H, Tsukamoto K, Yatomi Y
    • Journal Title

      J Diabetes Investig

      Volume: 5 Issue: 6 Pages: 639

    • DOI

      10.1111/jdi.12232

    • URL

      https://localhost/en/publications/984ce0ce-1d2a-4cca-a5fc-71bfd9f5ef01

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Induction of insulin secretion by apolipoprotein M, a carrier for sphingosine 1-phosphate.2014

    • Author(s)
      Kurano M, Hara M, Tsuneyama K, Sakoda H, Shimizu T, Tsukamoto K, Ikeda H, Yatomi Y.
    • Journal Title

      Biochim Biophys Acta.

      Volume: 1841 Issue: 9 Pages: 1217-1226

    • DOI

      10.1016/j.bbalip.2014.05.002

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Modulation of sphingosine-1-phosphate and apolipoprotein M levels in the plasma, liver and kidneys in streptozotocin-induced diabetic mice2014

    • Author(s)
      Takahiro Nojiri, Makoto Kurano, Yasunori Tokuhara, Shigeo Ohkubo, Masumi Hara, Hitoshi Ikeda, Kazuhisa Tsukamoto, Yutaka Yatomi
    • Journal Title

      Journal of Diabetes Investigation

      Volume: in press

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Liver involvement in sphingosine 1-phosphate dynamism revealed by adenoviral hepatic overexpression of apolipoprotein M2013

    • Author(s)
      Makoto Kurano, Kazuhisa Tsukamoto, Ryunosuke Ohkawa, Masumi Hara, Junko Iino, Yuko Kageyama, Hitoshi Ikeda, and Yutaka Yatomi
    • Journal Title

      atherosclerosis

      Volume: 229 Pages: 102-109

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] リゾリン脂質と肝臓2014

    • Author(s)
      蔵野 信
    • Organizer
      第54回日本臨床化学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] streptozotocin誘発型糖尿病マウスにおけるsphingosine 1-phosphateおよびapolipoprotein Mの変動2014

    • Author(s)
      野尻 卓宏, 蔵野 信, 大久保 滋夫, 池田 均, 矢冨 裕
    • Organizer
      第54回日本臨床化学会学術集会
    • Place of Presentation
      東京
    • Year and Date
      2014-09-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] アポ蛋白M-スフィンゴシン1-リン酸経路を介した,糖代謝の恒常性維持における肝臓の役割.2014

    • Author(s)
      蔵野 信,原 眞純,常山 幸一,迫田 秀之,野尻 卓宏,塚本 和久,矢冨 裕.
    • Organizer
      第57回 日本糖尿病学会学術集会
    • Place of Presentation
      大阪
    • Year and Date
      2014-05-24
    • Related Report
      2014 Annual Research Report
  • [Presentation] 血漿スフィンゴシン1-リン酸がアポ蛋白B含有リポ蛋白と正の相関を示す機序についての解明

    • Author(s)
      蔵野 信、大川 龍之介、小野 佳一、池田 均、矢冨 裕
    • Organizer
      第60回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] 糖代謝関連因子のアポ蛋白M、スフィンゴシン1-リン酸代謝に関する影響の検討

    • Author(s)
      野尻 卓宏、蔵野 信、大川 龍之介、大久保 滋夫、横田 浩充、池田 均、矢冨 裕
    • Organizer
      第60回日本臨床検査医学会学術集会
    • Place of Presentation
      神戸
    • Related Report
      2013 Research-status Report
  • [Presentation] アポ蛋白M-スフィンゴシン1-リン酸含有リポ蛋白代謝におけるLDL受容体、アポ蛋白Eの役割

    • Author(s)
      蔵野 信、大川 龍之介、池田 均、矢冨 裕
    • Organizer
      第53回日本臨床化学会年次学術集会
    • Place of Presentation
      徳島
    • Related Report
      2013 Research-status Report
  • [Presentation] アポ蛋白Mを通じたスフィンゴシン1-リン酸学の構築

    • Author(s)
      蔵野 信
    • Organizer
      日本臨床検査医学会 第25回関東・甲信越支部総会
    • Place of Presentation
      東京
    • Related Report
      2013 Research-status Report
    • Invited
  • [Remarks] 東京大学 医学部附属病院 検査部 研究紹介

    • URL

      http://lab-tky.umin.jp/research/index.html

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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