Research on mechanisms regulating incretin secretion by nutrients

• Project/Area Number: 25860748
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Metabolomics
• Research Institution: Kobe University
• Principal Investigator: Daisuke Yabe 神戸大学, 医学(系)研究科(研究院), 准教授 (60378643)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000); Fiscal Year 2015: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000); Fiscal Year 2013: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000)
• Keywords: インクレチン / 栄養素 / 食べる順番 / 糖尿病 / GIP分泌 / GLP-1分泌 / 代謝シグナル

Outline of Final Research Achievements

Mechanisms regulating incretin secretion in response to various nutrients were investigated in humans and cultured cells. Cultured cell models were established to study signaling and metabolism underlying regulation of incretin secretion. Varying incretin response to nutrients were evaluated in humans. Notably, order of nutrients exposed affect incretin secretion. This study now gains strong attention as medical nutritional therapy for management of type 2 diabetes.

Research Products

• [Int'l Joint Research] University of Copenhagen(デンマーク)
• [Int'l Joint Research]
• [Journal Article] Incretin-based drugs for type 2 diabetes: Focus on East Asian perspectives (2016)
  • Author(s): Seino Y, Kuwata H, Yabe D
  • Journal Title: J Diabetes Investig Volume: 7 Issue: S1 Pages: 102-109
  • DOI: 10.1111/jdi.12490
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Endogenous GIP ameliorates impairment of insulin secretion in proglucagon-deficient mice under moderate beta cell damage induced by streptozotocin. (2016)
  • Author(s): Iida A, Seino Y, Fukami A, Maekawa R, Yabe D, Shimizu S, Kinoshita K, Takagi Y, Izumoto T, Ogata H, Ishikawa K, Ozaki N, Tsunekawa S, Hamada Y, Oiso Y, Arima H, Hayashi Y.
  • Journal Title: Diabetologia Volume: x Issue: 7 Pages: 1533-1541
  • DOI: 10.1007/s00125-016-3935-2
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Meal sequence and glucose excursion, gastric emptying and incretin secretion in type 2 diabetes: A randomized, controlled cross-over, exploratory trial. (2016)
  • Author(s): Kuwata H, Iwasaki M, Shimizu S, Minami K, Maeda H, Seino S, Nakada K, Nosaka C, Murotani K, Kurose T, Seino Y, Yabe D.
  • Journal Title: Diabetologia Volume: 59 Issue: 3 Pages: 453-461
  • DOI: 10.1007/s00125-015-3841-z
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Type 2 diabetes via β-cell dysfunction in east Asian people. (2016)
  • Author(s): Yabe D, Seino Y.
  • Journal Title: Lancet Diabetes Endocrinol Volume: 4 Issue: 1 Pages: 2-3
  • DOI: 10.1016/s2213-8587(15)00389-7
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Glucagon-like peptide-1 receptor agonist therapeutics for total diabetes management: Assessment of composite end-points (2015)
  • Author(s): Yabe D, Kuwata H, Usui R, Kurose T, Seino Y
  • Journal Title: Curr Med Res Opin Volume: NA Issue: 7 Pages: 1267-1270
  • DOI: 10.1185/03007995.2015.1045471
  • Peer Reviewed / Open Access
• [Journal Article] Retrospective analysis of safety and efficacy of liraglutide monotherapy and sulfonylurea-combination therapy in Japanese type 2 diabetes: Association of remaining β-cell function and achievement of HbA1c target one year after initiation. (2015)
  • Author(s): Usui R, Yabe D, Kuwata H, Murotani K, Kurose T, Seino Y.
  • Journal Title: J Diabetes Complications Volume: 29 Issue: 8 Pages: 1203-1210
  • DOI: 10.1016/j.jdiacomp.2015.07.020
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] β Cell Dysfunction Versus Insulin Resistance in the Pathogenesis of Type 2 Diabetes in East Asians (2015)
  • Author(s): Yabe D, Seino Y, Fukushima M, Seino S
  • Journal Title: Curr Diab Rep Volume: NA Issue: 6 Pages: 602-602
  • DOI: 10.1007/s11892-015-0602-9
  • Peer Reviewed / Open Access
• [Journal Article] Early phase glucagon and insulin secretory abnormalities, but not incretin secretion, are similarly responsible for hyperglycemia after ingestion of nutrients (2015)
  • Author(s): Yabe D, Kuroe A, Watanabe K, Iwasaki M, Hamasaki A, Hamamoto Y, Harada N, Yamane S, Lee S, Murotani K, Deacon CF, Holst JJ, Hirano T, Inagaki N, Kurose T, Seino Y
  • Journal Title: J Diabetes Complications Volume: 29 Issue: 3 Pages: 413-421
  • DOI: 10.1016/j.jdiacomp.2014.12.010
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Use of the Japanese health insurance claims database to assess the risk of acute pancreatitis in patients with diabetes: comparison of DPP-4 inhibitors with other oral antidiabetic drugs (2015)
  • Author(s): Yabe D, Kuwata H, Kaneko M, Ito C, Nishikino R, Murorani K, Kurose T, Seino Y
  • Journal Title: Diabetes Obes Metab Volume: 17 Issue: 4 Pages: 430-434
  • DOI: 10.1111/dom.12381
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] A case of hypoglycemia due to illegitimate sexual enhancement medication (2015)
  • Author(s): Kuramoto N, Yabe D, Kurose T, Seino Y
  • Journal Title: Diabetes Res Clin Pract Volume: 108 Issue: 1 Pages: e8-e10
  • DOI: 10.1016/j.diabres.2015.02.014
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Efficacy and safety of lixisenatide in Japanese patients with type 2 diabetes mellitus inadequately controlled by sulfonylurea with or without metformin: Subanalysis of GetGoal-S (2015)
  • Author(s): Onishi Y, Niemoeller E, Ikeda, Y, Takagi H, Yabe D, Seino Y
  • Journal Title: J Diabetes Investig Volume: 6 Issue: 2 Pages: 201-209
  • DOI: 10.1111/jdi.12275
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Short-term impacts of sodium/glucose co-transporter 2 inhibitors in Japanese clinical practice: considerations for their appropriate use to avoid serious adverse events. (2015)
  • Author(s): Yabe D, Nishikino R, Kaneko M, Iwasaki M, Seino Y
  • Journal Title: Expert Opin Drug Saf Volume: NA Issue: 6 Pages: 795-800
  • DOI: 10.1517/14740338.2015.1034105
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Why are incretin-based therapies more efficient in East Asians? Perspectives from the pathophysiology of type 2 diabetes and East Asian dietary habit (2015)
  • Author(s): Yabe D, Kuwata H, Iwasaki M, Seino Y
  • Journal Title: European Medical Journal Volume: NA
  • Peer Reviewed
• [Journal Article] Efficacy and safety of lixisenatide in Japanese patients with type 2 diabetes insufficiently controlled with basal insulin ± sulfonylurea: a subanalysis of the GetGoal-L-Asia study (2015)
  • Author(s): Seino Y, Ikeda Y, Niemoeller E, Watanabe D, Takagi H, Yabe D, Inagaki N
  • Journal Title: Hormone and Metabolic Research Volume: NA
  • Peer Reviewed
• [Journal Article] Alogliptin benzoate for the treatment of type 2 diabetes (2014)
  • Author(s): Seino Y, Yabe D
  • Journal Title: Expert Opin Pharmacother Volume: 15 Issue: 6 Pages: 851-63
  • DOI: 10.1517/14656566.2014.898750
  • Peer Reviewed
• [Journal Article] Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects (2014)
  • Author(s): Kurashina T, Nagasaka S, Watanabe N, Yabe D, Sugi N, Nin K, Hosokawa M, Nomura Y, Fukushima M, Nakai Y, Nishimura F, Taniguchi A
  • Journal Title: Journal of Atherosclerosis and Thrombosis Volume: 21 Issue: 7 Pages: 730-738
  • DOI: 10.5551/jat.21055
  • NAID: 130004677960
  • ISSN: 1340-3478, 1880-3873
  • Peer Reviewed / Open Access
• [Journal Article] Time to do more: addressing clinical inertia in the management of type 2 diabetes mellitus (2014)
  • Author(s): train WD, Cos X, Hirst M, Venciod S, Mohan V, Vokó Z, Yabe D, Blüher M, Paldánius PM
  • Journal Title: Diabetes Res Clin Pract Volume: 105 Issue: 3 Pages: 302-312
  • DOI: 10.1016/j.diabres.2014.05.005
  • Peer Reviewed
• [Journal Article] Factors influencing durability of the glucose-lowering effect of sitagliptin combined with a sulfonylurea (2014)
  • Author(s): Kubota A, Yabe D, Kanamori A, Kuroe A, Takahashi N, Saito T, Matsuba I, Nabe K, Kurose T, Seino Y
  • Journal Title: J Diabetes Investig Volume: 5 Issue: 4 Pages: 445-448
  • DOI: 10.1111/jdi.12182
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or foe? (2014)
  • Author(s): Yabe D, Seino Y
  • Journal Title: J Diabetes Investig Volume: 5 Issue: 5 Pages: 475-477
  • DOI: 10.1111/jdi.12229
  • Peer Reviewed / Open Access
• [Journal Article] Relationship and factors responsible for regulating fasting and post-challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus (2014)
  • Author(s): Aoyama-Sasabe S, Xin X, Taniguchi A, Nakai Y, Mitsui R, Tsuji H, Yabe D, Yasuda K, Kurose, T, Inagaki N, Seino Y, Fukushima, M
  • Journal Title: J Diabetes Investig Volume: 5 Issue: 6 Pages: 663-670
  • DOI: 10.1111/jdi.12239
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Defining the role of GLP-1 receptor agonists for individualized treatment of type 2 diabetes (2014)
  • Author(s): Yabe D, Seino Y
  • Journal Title: Expert Review of Endocrinology and Metabolism Volume: 9 Issue: 6 Pages: 659-670
  • DOI: 10.1586/17446651.2014.949672
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] The role of chronobiology and circadian rhythms in type 2 diabetes mellitus: implications for management of diabetes (2014)
  • Author(s): Kurose T, Hyo T, Yabe D, Seino Y
  • Journal Title: ChronoPhysiology and Therapy Volume: 4 Pages: 41-49
  • DOI: 10.2147/cpt.s44804
  • Peer Reviewed / Open Access
• [Journal Article] Factors influencing durability of the glucose-lowering effect of sitagliptin combined with a sulfonylurea (2014)
  • Author(s): Kubota A, Yabe D, Kanamori A, Kuroe A, Takahashi N, Saito T,Matsuba I, Nabe K, Kurose T, Seino Y.
  • Journal Title: J Diabet Investig Volume: -
  • Peer Reviewed
• [Journal Article] The relationship and factors responsible for regulating fasting and post-challenge plasma glucose levels in the early stage development of type 2 diabetes mellitus. (2014)
  • Author(s): Sasabe S.A., Xin X, Taniguchi A, Nakai Y, Mitsui R, Tsuji H, Yabe D, Yasuda K, Kurose, T, Inagaki N, Seino Y, Fukushima, M.
  • Journal Title: J Diabet Investig Volume: -
  • Peer Reviewed
• [Journal Article] Circulating TNF Receptor 2 is Closely Associated with the Kidney Function in Non-Diabetic Japanese Subjects. (2014)
  • Author(s): Kurashina T, Nagasaka S, Watanabe N, Yabe D, Sugi N, Nin K, Hosokawa M, Nomura Y, Fukushima M, Nakai Y, Nishimura F, Taniguchi A.
  • Journal Title: J Atheroscler Thromb Volume: -
  • NAID: 130004677960
  • Peer Reviewed
• [Journal Article] Time 2 Do More: Addressing Clinical Inertia in the Management of Type 2 Diabetes mellitus. (2014)
  • Author(s): Strain WD, Cos X, Hirst M, Venciod S, Mohan V, Vokó Z, Yabe D, Blüher M, Paldánius PM
  • Journal Title: DRCP Volume: -
  • Peer Reviewed
• [Journal Article] Alogliptin Benzoate for the Treatment of Type 2 Diabetes. (2014)
  • Author(s): Seino Y, Yabe D
  • Journal Title: Expert Opinion On Pharmacotherapy Volume: 15 Pages: 851-863
  • Peer Reviewed
• [Journal Article] Dipeptidyl peptidase-4 inhibitors and sulfonylureas for type 2 diabetes: Friend or Foe? (2014)
  • Author(s): Yabe D, Seino Y
  • Journal Title: J Diabet Invest Volume: -
  • Peer Reviewed
• [Journal Article] Enhanced glucagon-like peptide-1 secretion in a patient with glucagonoma: Implications for glucagon-like peptide-1 secretion from pancreatic alpha cells in vivo (2013)
  • Author(s): Yabe D, Rokutan M, Komoto I, Usui R, Kuwata H, Watanabe K, Hyo T, Kurose T, Nagamatsu T, Shimizu S, Kawai J, Imamura M, Seino Y.
  • Journal Title: DRCP Volume: 102
  • Peer Reviewed
• [Journal Article] GIP and GLP-1: Incretin actions beyond pancreas. (2013)
  • Author(s): Seino Y, Yabe D
  • Journal Title: J Diabet Invest Volume: 4 Pages: 108-130
  • Peer Reviewed
• [Journal Article] Incretin actions beyond the pancreas: lessons from knockout mice. (2013)
  • Author(s): Yabe D, Seino Y
  • Journal Title: Current Opinion in Pharmacology Volume: 13 Pages: 946-953
  • Peer Reviewed
• [Presentation] 病態栄養学を基軸とした２型糖尿病の病態理解と科学的根拠にもとづく栄養療法確立に向けて (2016)
  • Author(s): 矢部大介
  • Organizer: 第１９回日本病態栄養学会年次学術集会
  • Place of Presentation: 横浜
  • Year and Date: 2016-01-09
  • Invited
• [Presentation] Incretin-based therapy for type 2 diabetes: Focus on East Asian perspectives and hypoglycemia (2015)
  • Author(s): Daisuke Yabe
  • Organizer: 7th Asian Association for the Study of Diabetes Scientific Meeting
  • Place of Presentation: 香港
  • Year and Date: 2015-11-21
  • Int'l Joint Research / Invited
• [Presentation] Efficacy and Safety of Incretin-Based Therapies in Asian Clinical Use (2015)
  • Author(s): Daisuke Yabe
  • Organizer: Incretin 2015
  • Place of Presentation: バンクーバー
  • Year and Date: 2015-07-29
  • Int'l Joint Research / Invited
• [Presentation] インクレチン関連薬の臨床における有用性と安全性 ～実臨床とレセプトデータの解析を中心に～ (2015)
  • Author(s): 矢部大介、清野裕
  • Organizer: 第５８回日本糖尿病学会年次学術集会
  • Place of Presentation: 下関
  • Year and Date: 2015-05-23
  • Invited
• [Presentation] Diet and Medication in the Management of Type 2 Diabetes: Promising Fingsings in an Old Couple (2015)
  • Author(s): Daisuke Yabe
  • Organizer: 12th Asian Congress of Nutrition
  • Place of Presentation: 横浜
  • Year and Date: 2015-05-14
  • Int'l Joint Research / Invited
• [Presentation] Why are incretin-based therapies more efficient in East Asians (2014)
  • Author(s): Daisuke Yabe, Hitoshi Kuwata, Masahiro Iwasaki, Yutaka Seino
  • Organizer: 10th International Diabetes Federation Western Pacific Region Congress/6th Asian Association for the Study of Diabetes Scientific Meeting
  • Place of Presentation: Singapore
  • Year and Date: 2014-11-21 – 2014-11-24
  • Invited
• [Presentation] Incretin-based drugs and nutritional therapies: better diets to improve long-term glucose-lowering effects. (2014)
  • Author(s): Daisuke Yabe, Hitoshi Kuwata, Masahiro Iwasaki, Yutaka Seino
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-09-15 – 2014-09-19
  • Invited
• [Presentation] Why are incretin-based therapies more efficient in East Asians (2014)
  • Author(s): Masahiro Iwasaki, Daisuke Yabe, Hitoshi Kuwata, Yutaka Seino
  • Organizer: 50th Annual Meeting of European Association for Study of Diabetes
  • Place of Presentation: Vienna, Austria
  • Year and Date: 2014-09-15 – 2014-09-19
  • Invited
• [Presentation] GLP-1受容体作動薬 (2014)
  • Author(s): 矢部大介、清野裕
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-23 – 2014-05-25
  • Invited
• [Presentation] Long actingへの期待 (2014)
  • Author(s): 矢部大介、清野裕
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 大阪
  • Year and Date: 2014-05-23 – 2014-05-25
  • Invited
• [Presentation] インクレチン療法の作用を高める食事療法の確立に向けて：食べる順番がインクレチン分泌、血糖変動に与える影響について (2014)
  • Author(s): 矢部大介、桑田仁司、岩崎真宏、清野裕
  • Organizer: 第17回日本病態栄養学会年次学術集会
  • Place of Presentation: 大阪
  • Invited
• [Presentation] 日本人２型糖尿病患者におけるインクレチン関連薬の長期有効性とそれにかかわる因子の解析 (2013)
  • Author(s): 矢部大介、清野裕
  • Organizer: 第57回日本糖尿病学会年次学術集会
  • Place of Presentation: 熊本
  • Invited
• [Presentation] Education for Diabetes Self-Management (2013)
  • Author(s): Daisuke Yabe
  • Organizer: Asia-Pacific Diabetes, Epidemiology and Education Training Course 2013
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Diabetes Prevention Program: Japanese Experience (2013)
  • Author(s): Daisuke Yabe
  • Organizer: Asia-Pacific Diabetes, Epidemiology and Education Training Course 2013
  • Place of Presentation: Seoul, Korea
  • Invited
• [Presentation] Beyond Glycemic Control: From Gut to the Heart and More (2013)
  • Author(s): Daisuke Yabe
  • Organizer: The Autumn Meeting of The Endocrine Society of the R.O.C. (Taiwan)
  • Place of Presentation: Tainan, ROC
  • Invited
• [Presentation] Debate: Incretin related therapies increase risk of acute pancreatitis or pancreatic cancer? - No (2013)
  • Author(s): Daisuke Yabe
  • Organizer: 5th the Asian Association for the Study of Diabetes Scientific Meeting
  • Place of Presentation: Seoul, Korea
  • Invited