Mifepristone improved Diet-induced insulin resistance by increasing blood level of adiponectin.
| Project/Area Number |
25860770
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Endocrinology
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| Research Institution | Kagawa University |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥910,000 (Direct Cost: ¥700,000、Indirect Cost: ¥210,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
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| Keywords | 前駆脂肪細胞 / 成熟脂肪細胞 / グルココルチコイド / デキサメタゾン / 脂肪細胞分化 / スフィンゴ脂質 / S1P / スフィンゴシンキナーゼ |
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| Outline of Final Research Achievements |
Mifepristone is known as a steroid receptor antagonist and is clinically used as an anti-cancer agent. This study aimed to determine whether mifepristone influences insulin sensitivity and adiponectin secretion both in in vivo and in vitro. First, we explored the effects of mifepristone, on metabolic functions in obese mice. When these mice were fed mifepristone, they exhibited a marked improvement in insulin sensitivity, and attenuated hepatic injury, compared with mice that received only the high-fat diet. Intriguingly, mifepristone-treated mice showed significantly elevated plasma adiponectin levels. Second, we tested the effects of mifepristone on differentiated adipocytes in vitro. When adipocytes were treated with mifepristone, adiponectin was upregulated at both mRNA and protein levels. These results uncover a possibility that long term administration of mifepristone leads to non-obese non-alcoholic fatty liver disease, associated with overeating or dyslipidemia.
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Report
(3 results)
Research Products
(7 results)
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[Journal Article] Hasan AU, Ohmori K, Konishi K, Igarashi J, Hashimoto T, Kamitori K, Yamaguchi F, Tsukamoto I, Uyama T, Ishihara Y, Noma T, Tokuda M, Kohno M.2015
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[Journal Article] Valsartan ameliorates the constitutive adipokine expression pattern in mature adipocytes: a role for inverse agonism of the angiotensin II type 1 receptor in obesity2014
Author(s)
Hasan AU, Ohmori K, Hashimoto T., Kamitori K, Yamaguchi F, Ishihara Y, Ishihara N, Noma T, Tokuda M, Kohno M,
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Journal Title
Hypertens Res
Volume: 37(7)
Pages: 621-628
Related Report
Peer Reviewed / Acknowledgement Compliant
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