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Establishment of the iPS cells derived from the paroxysmal nocturnal hemoglobinuria clone cells and its application to a study of bone marrow failure.

Research Project

Project/Area Number 25860785
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Hematology
Research InstitutionThe University of Tokyo

Principal Investigator

WATADANI Kumi  東京大学, 医学部附属病院, 助教 (70550432)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Keywords発作性夜間色素性尿症 / iPS細胞 / 発作性夜間ヘモグロビン尿症 / 多能性幹細胞 / PNH
Outline of Final Research Achievements

Establishment of induced pluripotent stem (iPS) cells derived from the affected cells of bone marrow failure including paroxysmal nocturnal hemoglobinuria is under investigation now. The object of this study is to establish the disease-specific iPS cells derived from PNH clone cells effectively and to promote elucidating the etiology of the disease by analyzing the hematopoietic cells differentiated from the iPS cells. We conducted trying induce iPS cells by reprogramming the PNH clone cells with CD55 negative and CD 59 negative populations of the bone marrow or the peripheral blood of classical PNH cases by use of Sendai virus vectors and non-viral episomal vectors.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (2 results)

All Other

All Remarks (2 results)

  • [Remarks]

    • URL

      http://www.u-tokyo-hemat.com/

    • Related Report
      2014 Annual Research Report
  • [Remarks] 東京大学医学部附属病院 血液・腫瘍内科

    • URL

      http://www.u-tokyo-hemat.com/

    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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