Investigation of Tie1 signaling in hematopoietic stem cells

• Project/Area Number: 25860799
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Hematology
• Research Institution: National Institute of Infectious Diseases
• Principal Investigator: Momose Haruka 国立感染症研究所, その他部局等, 研究員 (70415488)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000); Fiscal Year 2015: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2014: ¥1,690,000 (Direct Cost: ¥1,300,000、Indirect Cost: ¥390,000); Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
• Keywords: 造血幹細胞 / 造血細胞 / 受容体型チロシンキナーゼ

Outline of Final Research Achievements

Hematopoietic stem cells (HSCs) possess self-renewal and pluripotential capacity for the maintenance of whole blood system. The regulation of HSCs is very important for blood homeostasis, however, the precise molecular mechanisms regulating HSCs remain elusive. In this work, I investigated about an orphan receptor Tie1. The forced expression of Tie1 had no effect on the cell growth and the gene expression patterns. Interestingly, some molecules induced the phosphorylation of Tie1, indicating the trans-activation of Tie1 in hematopoietic cells.