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Elucidation of the regulatory T cell induction mechanism by IL-27 -towards novel therapy for SLE-

Research Project

Project/Area Number 25860803
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionThe University of Tokyo

Principal Investigator

IWASAKI Yukiko  東京大学, 医学部附属病院, 助教 (30592935)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
KeywordsIL-27 / 制御性T細胞 / Egr2 / 制御性T細胞 / 全身性エリテマトーデス / LAG3
Outline of Final Research Achievements

We have recently reported the CD4+CD25-LAG3+ new regulatory T cells (LAG3 Treg), which specifically express the transcriptional factor early response gene 2 (Egr2). The applicant has already found that interleukin (IL)-27 cytokine can induce both Egr2 and LAG3 on naive CD4-positive T cells. In this project, it was shown that the IL-27-induced CD4-positive T cells can suppress antibody production from B cells. In addition, the applicant revealed that IL-27 signal can be transduced by the transcriptional factor signal transducer and activator of transcription 3 (STAT3), resulting in Egr2 expression. These findings provide insights into the novel therapeutic potential for systemic lupus erythematosus (SLE).

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (5 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (3 results)

  • [Journal Article] TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses2015

    • Author(s)
      Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, Komai T, Shoda H, Miyazaki J, Fujio K, Yamamoto K.
    • Journal Title

      Nature Communications

      Volume: 6 Issue: 1 Pages: 1-14

    • DOI

      10.1038/ncomms7329

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Interleukin-27 in T cell immunity.2015

    • Author(s)
      Iwasaki Y, Fujio K, Okamura T, Yamamoto K
    • Journal Title

      Int J Mol Sci

      Volume: 16 Issue: 2 Pages: 2851-63

    • DOI

      10.3390/ijms16022851

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Egr-2 transcription factor is required for Blimp-1 mediated IL-10 production in IL-27 stimulated CD4(+) T cells2013

    • Author(s)
      Iwasaki, Y.
    • Journal Title

      Eur J Immunol

      Volume: undefined Issue: 4 Pages: 1063-73

    • DOI

      10.1002/eji.201242942

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] IL-27による免疫制御機構2013

    • Author(s)
      岩崎由希子
    • Journal Title

      臨床免疫・アレルギー科

      Volume: 59 Pages: 282-287

    • Related Report
      2013 Research-status Report
  • [Journal Article] Toward therapeutic application of IL-10-producing regulatory T cells2013

    • Author(s)
      Yukiko Iwasaki, Keishi Fujio, Tomohisa Okamura, Atsushi Yanai, Kazuhiko Yamamoto
    • Journal Title

      Nihon Rinsho Meneki Gakkai Kaishi

      Volume: 36 Pages: 40-46

    • Related Report
      2013 Research-status Report
  • [Presentation] IL-27 induces regulatory T cells that suppress B cell responses2014

    • Author(s)
      Y. Iwasaki, T. Okamura, K.Morita, M. Inoue, S. Sumitomo, K. Fujio, K. Yamamoto1
    • Organizer
      第43会日本免疫学会学術集会
    • Place of Presentation
      国立京都国際会館
    • Year and Date
      2014-12-10 – 2014-12-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] Transcription factor Egr-2 mediates IL-27-induced IL-10 production in CD4+ T cells2013

    • Author(s)
      Yukiko Iwasaki, Keishi Fujio, Tomohisa Okamura, Atsushi Yanai, Shuji Sumitomo, Tomohiko Tamura, Hiroki Yoshida, Kazuhiko Yamamoto
    • Organizer
      第5回EAGOR (East Asian Group of Rheumatology) meeting
    • Place of Presentation
      The Plaza, Seoul, Korea
    • Related Report
      2013 Research-status Report
  • [Presentation] Novel IL-10 induction pathway mediated by Egr-2 in IL-27-stimulated T cells2013

    • Author(s)
      Yukiko Iwasaki, Keishi Fujio, Tomohisa Okamura, Atsushi Yanai, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto
    • Organizer
      第57回日本リウマチ学会総会・学術集会
    • Place of Presentation
      国立京都国際会館
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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