The role of Sirt1 in arthritis

• Project/Area Number: 25860807
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Collagenous pathology/Allergology
• Research Institution: University of Toyama
• Principal Investigator: HOUNOKI Hiroyuki 富山大学, 大学病院, 助教 (90512088)
• Project Period (FY): 2013-04-01 – 2015-03-31
• Project Status: Completed (Fiscal Year 2014)
• Budget Amount: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000); Fiscal Year 2014: ¥1,300,000 (Direct Cost: ¥1,000,000、Indirect Cost: ¥300,000); Fiscal Year 2013: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
• Keywords: 免疫学 / 遺伝子 / 関節リウマチ / Sirt1 / 破骨細胞

Outline of Final Research Achievements

Rheumatoid arthritis ( RA )is inflammatory disease which may lead to joint destructionwithout treatment.Osteoclasts play a important role in joint destruction in RA.So,inhibition of differentiation of osteoclast may lead to the treatment of RA.We investicated the role of Sirt1 in differentiation of Osteoclast.It is indicated that Sirt1 may negatively regulate the differentiation of Osteoclasts　which play a important role in obstruction of joints in arthritis.