| Project/Area Number |
25860808
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | Kyoto University |
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Principal Investigator |
NAKASHIMA Ran 京都大学, 医学(系)研究科(研究院), 助教 (10599525)
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| Project Period (FY) |
2013-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2014: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Keywords | 皮膚筋炎 / 抗MDA5抗体 / 間質性肺炎 / 単球 / マクロファージ / 抗MDA抗体 / HLA |
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| Outline of Final Research Achievements |
The purpose was to investigate the pathophisiology of anti-MDA5-positive DM and the pathogenicity of MDA5 or anti-MDA5 antibody.
An autopsy of anti-MDA5-positive DM with rapidly progressive interstitial lung disease(ILD) revealed that a lot of macrophages infiltrated to alveoli in the lesion of ILD. Moreover, IP-10, which stimulate the activation of monocyte and macrophage, was highly expressed in the damaged alveoli and fibrotic change after inflammation. In vitro, it was suggested that anti-MDA5-positive IgG stimulated monocytes producing more IL-6 than normal control(NC) in the coexistence of poly I:C. MDA5 was detected more frequently in anti-MDA5-positive patients than NC and its concentration was also higher in the patients than in HC. Serum MDA5 may react with anti-MDA5 and play some role in the pathophisiology in anti-MDA5-positive DM. HLA DRB1＊13:02-DQB1＊06:04 -DQB1＊06:04 was associated with anti-MDA5-positive dermatomyositis as a genetic background.
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