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A novel treatment strategy aiming joint regeneration of rheumatoid arthritis and osteoarthritis by mesenchymal stem cells with nano-fiber scaffold

Research Project

Project/Area Number 25860821
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionUniversity of Occupational and Environmental Health, Japan

Principal Investigator

SONOMOTO Koshiro  産業医科大学, 医学部, 非常勤医師 (20636914)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2015: ¥780,000 (Direct Cost: ¥600,000、Indirect Cost: ¥180,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords関節再生 / 関節リウマチ / スキャフォールド / 変形性関節症 / 再生医療 / 間葉系幹細胞
Outline of Final Research Achievements

Mesenchymal stem cells (MSCs) have immunosuppressive activity and can differentiate into bone and cartilage; and thus seem ideal for treatment of rheumatoid arthritis (RA) and osteoarthritis (OA). Here, we investigated the immunosuppressive potential, osteogenesis and chondrogenesis potentials of MSCs seeded onto nano-fiber scaffolds (NFs). Healthy donor derived human MSC seeded on NF sheet (NF-MSC) successfully suppressed the collagen induced arthritis of rats. In this context, NFs enhanced the ability of MSCs of cytokines production. Next, in vitro experiment of NF-MSC revealed that NFs stimulated the differentiation of MSCs derived from healthy as well as RA- or OA-patients into osteoblasts, chondrocytes and osteocytes. These data show the possible use of NF-MSCs for the repair of RA-affected joints.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2014 2013

All Journal Article (3 results) (of which Peer Reviewed: 3 results,  Open Access: 2 results,  Acknowledgement Compliant: 1 results) Presentation (1 results)

  • [Journal Article] Spontaneous differentiation of human mesenchymal stem cells on poly-lactic-co-glycolic acid nano-fiber scaffold2016

    • Author(s)
      Koshiro Sonomoto, Kunihiro Yamaoka, Hiroaki Kaneko, Kaoru Yamagata, Kei Sakata, Xiangmei Zhang, Masahiro Kondo, Yukichi Zenke, Ken Sabanai, Shingo Nakayamada, Akinori Sakai, Yoshiya Tanaka
    • Journal Title

      PLOS ONE

      Volume: in press Issue: 4 Pages: e0153231-e0153231

    • DOI

      10.1371/journal.pone.0153231

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Local Delivery of Mesenchymal Stem Cells with Poly-Lactic-Co-Glycolic Acid Nano-Fiber Scaffold Suppress Arthritis in Rats2014

    • Author(s)
      Xiangmei Zhang, Kunihiro Yamaoka, Koshiro Sonomoto, Hiroaki Kaneko, Makoto Satake, Yuka Yamamoto, Masahiro Kondo, Jidong Zhao, Ippei Miyagawa, Kaoru Yamagata, Shunsuke Fukuyo, Yosuke Okada, Yoshiya Tanaka
    • Journal Title

      PLOSONE

      Volume: - Issue: 12 Pages: e114621-e114621

    • DOI

      10.1371/journal.pone.0114621

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access
  • [Journal Article] The non-canonical Wnt5a/Ror2 signaling pathway in bone metabolism2014

    • Author(s)
      Koshiro Sonomoto, Kunihiro Yamaoka and Yoshiya Tanaka
    • Journal Title

      Inflammation and Regeneration

      Volume: 34 Pages: 103-108

    • NAID

      130004482325

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] IL-17によるヒト間葉系幹細胞の軟骨細胞分化抑制作用の解析2013

    • Author(s)
      近藤正弘、山岡邦宏、園本格士朗、福與俊介、尾下浩一、岡田洋右、齋藤和義、田中良哉
    • Organizer
      第57回日本リウマチ学会
    • Place of Presentation
      京都国際会館
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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