Mechanisms of non atopic airway inflammation
| Project/Area Number |
25860822
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Collagenous pathology/Allergology
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| Research Institution | National Research Institute for Child Health and Development |
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Principal Investigator |
MORITA Hideaki 独立行政法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 研究員 (90365320)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
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| Keywords | 気道炎症 / IL-33 / マスト細胞 / 制御性T細胞 / 自然免疫リンパ球 / プロテアーゼ |
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| Outline of Final Research Achievements |
We found that the plant-derived cysteine protease, which is homologous to house dust mite protease, induce production of IL-33 by lung epithelial cells, resulting in development of allergic eosinophilic airway inflammation. We also found that IL-33 can play an anti-inflammatory/immunosuppressive negative-feedback role by inducing regulatory T cells through mast cells while promoting allergic inflammation through innate lymphoid cells
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Report
(3 results)
Research Products
(8 results)
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[Journal Article] Mast cells can suppress papain-induced natural helper-cell-mediated innate-type allergic inflammation2015
Author(s)
Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis C, Gali SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
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Journal Title
Immunity
Volume: In press
Related Report
Peer Reviewed / Acknowledgement Compliant
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