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Mechanisms of non atopic airway inflammation

Research Project

Project/Area Number 25860822
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Collagenous pathology/Allergology
Research InstitutionNational Research Institute for Child Health and Development

Principal Investigator

MORITA Hideaki  独立行政法人国立成育医療研究センター, 免疫アレルギー・感染研究部, 研究員 (90365320)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2014: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywords気道炎症 / IL-33 / マスト細胞 / 制御性T細胞 / 自然免疫リンパ球 / プロテアーゼ
Outline of Final Research Achievements

We found that the plant-derived cysteine protease, which is homologous to house dust mite protease, induce production of IL-33 by lung epithelial cells, resulting in development of allergic eosinophilic airway inflammation. We also found that IL-33 can play an anti-inflammatory/immunosuppressive negative-feedback role by inducing regulatory T cells through mast cells while promoting allergic inflammation through innate lymphoid cells

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (8 results)

All 2015 2014 2013

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (2 results) (of which Invited: 2 results) Book (2 results)

  • [Journal Article] Mast cells can suppress papain-induced natural helper-cell-mediated innate-type allergic inflammation2015

    • Author(s)
      Morita H, Arae K, Unno H, Miyauchi K, Toyama S, Nambu A, Oboki K, Ohno T, Motomura K, Matsuda A, Yamaguchi S, Narushima S, Kajiwara N, Iikura M, Suto H, Takahashi T, Karasuyama H, Okumura K, Azuma M, Moro K, Akdis C, Gali SJ, Koyasu S, Kubo M, Sudo K, Saito H, Matsumoto K, Nakae S.
    • Journal Title

      Immunity

      Volume: In press

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Silica and Double-Stranded RNA Synergistically Induce Bronchial Epithelial Apoptosis and Airway Inflammation2014

    • Author(s)
      Unno H, Futamura K, Morita H, Kojima R, Arae K, Nakae S, Ida H, Saito H, Matsumoto K, Matsuda A
    • Journal Title

      Am J Respir Cell Mol Biol

      Volume: (in press) Issue: 3 Pages: 344-353

    • DOI

      10.1165/rcmb.2013-0281oc

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Gastrointestinal Food Allergy in Infants2013

    • Author(s)
      Morita, H., I. Nomura, A. Matsuda, H. Saito, and K. Matsumoto
    • Journal Title

      Allergology International

      Volume: 62 Issue: 3 Pages: 297-307

    • DOI

      10.2332/allergolint.13-RA-0542

    • NAID

      130004477199

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Role of Interleukin-33 in Innate-Type Immune Cells in Allergy2013

    • Author(s)
      Nakae S, Morita H, Ohno T, Arae K, Matsumoto K, Saito H
    • Journal Title

      Allergology International

      Volume: 62 Issue: 1 Pages: 13-20

    • DOI

      10.2332/allergolint.13-RAI-0538

    • NAID

      130004477181

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] 抗原が含有するプロテアーゼによる炎症惹起とアレルギー疾患の発症に関するメカニズム2013

    • Author(s)
      森田 英明
    • Organizer
      第25回 日本アレルギー学会 春季臨床大会
    • Place of Presentation
      横浜
    • Related Report
      2013 Research-status Report
    • Invited
  • [Presentation] Non-IgE mediated food allergy2013

    • Author(s)
      Hideaki Morita
    • Organizer
      Asia Pacific Congress of Allergy, Asthma and Clinical Immunology 2013
    • Place of Presentation
      Taipei
    • Related Report
      2013 Research-status Report
    • Invited
  • [Book] 慢性アレルギー炎症のメカニズム2013

    • Author(s)
      斎藤博久、森田英明, 松本健治, 中江 進
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2013 Research-status Report
  • [Book] 細胞死によるアレルギー疾患への影響2013

    • Author(s)
      海野浩寿、森田英明、新江賢、大野建洲、斎藤博久、松本健治、中江進む
    • Total Pages
      6
    • Publisher
      羊土社
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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