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Prevalence of tumor viruses in malignancies and their possible role in the oncogenesis

Research Project

Project/Area Number 25860829
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionKochi University

Principal Investigator

Taniguchi Ayuko  高知大学, 教育研究部医療学系臨床医学部門, 助教 (30403885)

Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,950,000 (Direct Cost: ¥1,500,000、Indirect Cost: ¥450,000)
Keywordsウイルス / 腫瘍 / 微生物 / 感染症 / 癌
Outline of Final Research Achievements

Merkel cell polyomavirus (MCPyV) is the first polyomavirus that induces human malignancies. In this study, we investigate the prevalence of MCPyV in various malignancies. We described here our new findings on relationship between various viruses and glioblastoma multiforme (GBM), the most aggressive primary brain tumor. Recent studies stemmed from American and European populations showed that human cytomegalovirus (HCMV) DNA sequences were detected in a large portion of GBM, suggesting the pathogenetic role of HCMV in the development of GBM. The present study showed that any of our patients with GBM did not carry MCPyV in the tumors. In contrast with previous reports, our results did not support the association between HCMV and GBM. However, our investigations demonstrated the presence of the viral genome and protein of high-risk-type human papillomavirus (HPV) in a subset of Japanese patients with GBMs. Thus, HPV infection may play a potential etiological role in gliomagenesis.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (20 results)

All 2016 2015 2014 2013 Other

All Journal Article (7 results) (of which Peer Reviewed: 7 results,  Acknowledgement Compliant: 2 results,  Open Access: 1 results) Presentation (11 results) Book (1 results) Remarks (1 results)

  • [Journal Article] Epstein-Barr virus-positive pyothorax-associated lymphoma arising from a posttraumatic empyema.2015

    • Author(s)
      Ayuko Taniguchi, Yumiko Hashida, Yuiko Nemoto, Hisanori Machida, SungGi Chi, Takayuki Ikezoe, Akihito Yokoyama, Masanori Daibata
    • Journal Title

      Acta Haematologica

      Volume: 134 Issue: 3 Pages: 155-160

    • DOI

      10.1159/000380809

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Prevalence of human cytomegalovirus, polyomaviruses, and oncogenic viruses in glioblastoma among Japanese subjects.2015

    • Author(s)
      Yumiko Hashida, Ayuko Taniguchi, Toshio Yawata, Sena Hosokawa, Masanao Murakami, Makoto Hiroi, Tetsuya Ueba, Masanori Daibata.
    • Journal Title

      Infectious Agents and Cancer.

      Volume: 10 Issue: 1 Pages: 3-3

    • DOI

      10.1186/1750-9378-10-3

    • Related Report
      2014 Research-status Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] 多発性冠動脈内血栓症を併発しエクリズマブが著効した発作性夜間ヘモグロビン尿症2014

    • Author(s)
      谷口亜裕子、池添隆之、竹内麻子、砥谷和人、吉本光広、谷岡克敏、北岡裕章、横山彰仁
    • Journal Title

      臨床血液

      Volume: 55 Pages: 965-969

    • NAID

      130004688011

    • Related Report
      2014 Research-status Report
    • Peer Reviewed
  • [Journal Article] Phylogenetic analysis of Merkel cell polyomavirus based on full-length LT and VP1 gene sequences derived from neoplastic tumors in Japanese patients.2014

    • Author(s)
      Yumiko Hashida, Masayuki Imajoh, Mikio Kamioka, Ayuko Taniguchi, Naoto Kuroda, Kazuhiko Hayashi, Hideki Nakajima, Shigetoshi Sano, Masanori Daibata.
    • Journal Title

      Journal of General Virology

      Volume: 95 Issue: 1 Pages: 135-141

    • DOI

      10.1099/vir.0.058149-0

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Absence of Merkel cell polyomavirus in monocytic leukemias.2013

    • Author(s)
      Yumiko Hashida, Masayuki Imajoh, Ayuko Taniguchi, Mikio Kamioka, Masanori Daibata.
    • Journal Title

      Acta Haematologica

      Volume: 130 Issue: 3 Pages: 135-137

    • DOI

      10.1159/000347174

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Pyothorax-associated lymphoma (PAL) with biclonal Epstein–Barr virus infection: characterization of a novel PAL cell line with unique features.2013

    • Author(s)
      Ayuko Taniguchi, Yumiko Hashida, Yuiko Nemoto, Takahiro Taguchi, Yoshito Iwahara, Masanori Daibata.
    • Journal Title

      Leukemia Research

      Volume: 37 Issue: 11 Pages: 1545-1550

    • DOI

      10.1016/j.leukres.2013.07.033

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Journal Article] Effect of recom binant human soluble thrombomodulin on clinical outcomes of patients with coagulopathy after hematopoietic stem cell transplantation2013

    • Author(s)
      Ikezoe T, Takeuchi A, ChiS, Anabuki K, Kim T, Sakai M, Taniguchi A, Togitani K, Yokoyama A
    • Journal Title

      Eur J Haematol

      Volume: 91 Issue: 5 Pages: 442-447

    • DOI

      10.1111/ejh.12188

    • Related Report
      2013 Research-status Report
    • Peer Reviewed
  • [Presentation] Virus infection in glioblastoma multiforme (GBM): Possible association of human papillomavirus with pathogenesis of GBM.2015

    • Author(s)
      Yumiko Hashida, Ayuko Taniguchi, Toshio Yawata, Sena Hosokawa, Moe Tanaka, Masanao Murakami, Mikio Kamioka, Makoto Hiroi, Tetsuya Ueba, Masanori Daibata.
    • Organizer
      第63回日本ウイルス学会学術集会
    • Place of Presentation
      福岡国際会議場(福岡県・福岡市)
    • Year and Date
      2015-11-22
    • Related Report
      2015 Annual Research Report
  • [Presentation] Incidence and prophylaxis of herpes zoster in patients with myeloma in the era of novel agents.2015

    • Author(s)
      Masakazu Mori, Takayuki Ikezoe, Makoto Hiroi, Sunggi Chi, Yu Arakawa, Mizu Sakai, Ayuko Taniguchi, Kazuto Togitani, Akihito Yokoyama.
    • Organizer
      第77回日本血液学会学術総会
    • Place of Presentation
      石川県立音楽堂、ANAクラウンプラザホテル金沢、ホテル日航金沢、ホテル金沢、金沢市アートホール、もてなしドーム(石川県・石川市)
    • Year and Date
      2015-10-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] 好中球減少期に起こったStreptococcus mitis菌血症の検討2015

    • Author(s)
      荒川悠, 窪田哲也, 谷口亜裕子, 横山彰仁
    • Organizer
      第85回日本感染症西日本地方会学術集会
    • Place of Presentation
      奈良春日野国際フォーラム 甍~I・RA・KA、奈良ホテル(奈良県・奈良市)
    • Year and Date
      2015-10-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] 急激な経過で両手指の虚血性壊死をきたしたリンパ形質細胞性リンパ腫2015

    • Author(s)
      山本ゆい, 森正和, 弘井誠, 荒川悠, 池成基, 酒井瑞, 谷口亜裕子, 砥谷和人, 池添隆之, 横山彰仁
    • Organizer
      第55回日本リンパ網内系学会総会
    • Place of Presentation
      岡山コンベンションセンター(岡山県・岡山市)
    • Year and Date
      2015-07-09
    • Related Report
      2015 Annual Research Report
  • [Presentation] 膠芽腫におけるウイルス感染の調査2014

    • Author(s)
      橋田裕美子、八幡俊男、村上雅尚、谷口亜裕子、上岡樹生、上羽哲也、大畑雅典
    • Organizer
      日本ウイルス学会学術集会
    • Place of Presentation
      パシフィコ横浜(神奈川県・横浜市)
    • Year and Date
      2014-11-10 – 2014-11-12
    • Related Report
      2014 Research-status Report
  • [Presentation] A case of MDS with pulmonary manifestation and pathergy reaction test positive Sweet’s disease2014

    • Author(s)
      Yu Arakawa, Asako Takeuchi, SungGi Chi, Masato Takaoka, Tukie Tukuda, Kazuki Anabuki, Mizu Sakai, Sigeo Kawase, Ayuko Taniguchi, Hiroshi Ohnishi, Takayuki Ikezoe, Kazuto Togitani, Akihito Yokoyama
    • Organizer
      日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] Biosimilar filgrastim is comparable to reference products in managing neutropenia in lymphoma cases2014

    • Author(s)
      SungGi Chi, Takayuki Ikezoe, Masato Takaoka, Tukie Tukuda, Mizu Sakai, Asako Takeuchi, Ayuko Taniguchi, Kazuto Togitani, Akihito Yokoyama
    • Organizer
      日本血液学会学術集会
    • Place of Presentation
      大阪国際会議場(大阪府・大阪市)
    • Year and Date
      2014-10-31 – 2014-11-02
    • Related Report
      2014 Research-status Report
  • [Presentation] A case of Hodgkin lymphoma associated with chronic active Epstein-Barr virus infection.

    • Author(s)
      谷口亜裕子、池添隆之、砥谷和人、佐藤哲也、大畑雅典、横山彰仁
    • Organizer
      第11回日本臨床腫瘍学会学術集会
    • Place of Presentation
      仙台国際センター、東北大学百周年記念会館川内萩ホール(仙台市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Pulmonary complications as an independent prognostic factor in patients with hematologic malignancies.

    • Author(s)
      Hiroshi Ohnishi, Kazuto Togitani, Mizu Sakai, Ayuko Taniguchi, Takayuki Ikezoe, Tetsuya Kubota, Akihito Yokoyama.
    • Organizer
      18th Congress of the Asian Pacific Society of Respirology
    • Place of Presentation
      パシフィコ横浜 (横浜市)
    • Related Report
      2013 Research-status Report
  • [Presentation] Recombinant thrombomodulin improves clinical outcome in patients with coagulopathies after HSCT.

    • Author(s)
      Sunggi Chi, Takayuki Ikezoe, Asako Takeuchi, Kazuki Anabuki, Tsukie Kim, Mizu Sakai, Ayuko Taniguchi, Kazuto Togitani, Akihito Yokoyama.
    • Organizer
      第75回日本血液学会学術集会
    • Place of Presentation
      ロイトン札幌・さっぽろ芸文館・札幌市教育文化会館(札幌市)
    • Related Report
      2013 Research-status Report
  • [Presentation] 発作性夜間ヘモグロビン尿症に併発した繰り返す冠動脈内血栓症に対してエクリツマブが著効した一例

    • Author(s)
      江田 雅志、谷口 亜裕子、竹内 麻子、砥谷 和人、池添 隆之、吉本 光広、谷岡 克敏、北岡 裕章、横山 彰仁
    • Organizer
      第53回日本血液学会 中国四国地方会
    • Place of Presentation
      徳島大学蔵本キャンパス 大塚講堂(徳島市)
    • Related Report
      2013 Research-status Report
  • [Book] 血液フロンティア(EBウイルスが関与するホジキンリンパ腫)2016

    • Author(s)
      谷口亜裕子、大畑雅典
    • Total Pages
      148
    • Publisher
      医薬ジャーナル社
    • Related Report
      2015 Annual Research Report
  • [Remarks] 高知大学医学部

    • URL

      http://www.kochi-ms.ac.jp/

    • Related Report
      2014 Research-status Report

URL: 

Published: 2014-07-25   Modified: 2019-07-29  

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