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The pathogenesis of severe infections and the immunity in respiratory tract - New approach for anti-inflammatory treatment -

Research Project

Project/Area Number 25860830
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Infectious disease medicine
Research InstitutionNagasaki University

Principal Investigator

MORINAGA Yoshitomo  長崎大学, 医歯薬学総合研究科(医学系), 助教 (30580360)

Project Period (FY) 2013-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
KeywordsHMGB1 / 細胞死 / 気道免疫 / マクロライド / 肺炎 / 重症化 / 気道上皮
Outline of Final Research Achievements

TNFα contributes to the inhibition of bacterial growth in cells with inducting apoptotic cell death. Anaerobes produces some toxins and they may induces the receptors on the airway, which pneumococcus requires to attach to the respiratory tract. The toxins produced by anaerobes can progress the severity of pneumococcal pneumonia. The severity of infection may affect the effectiveness of antimicrobials in the treatment of pneumonia. Therefore, we need further studies for the evaluation of severity of infections and progress the strategies of choice the appropreate treatment.

Report

(3 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Research-status Report
  • Research Products

    (6 results)

All 2014 Other

All Journal Article (4 results) (of which Peer Reviewed: 4 results,  Acknowledgement Compliant: 1 results) Presentation (2 results)

  • [Journal Article] In vitro and in vivo activities of piperacillin-tazobactam and meropenem at different inoculum sizes of ESBL-producing Klebsiella pneumoniae2014

    • Author(s)
      Harada Y, Morinaga Y, Kaku N, Nakamura S, Uno N, Hasegawa H, Izumikawa K, Kohno S, Yanagihara K
    • Journal Title

      Clin Microbiol Infect

      Volume: 20 Issue: 11 Pages: 831-839

    • DOI

      10.1111/1469-0691.12677

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells.2014

    • Author(s)
      Yamada K, Morinaga Y, Yanagihara K, Kaku N, Harada Y, Uno N, Nakamura S, Imamura Y, Hasegawa H, Miyazaki T, Izumikawa K, Kakeya H, Mikamo H, Kohno S
    • Journal Title

      Pulm Pharmacol Ther

      Volume: 28 Issue: 2 Pages: 165-170

    • DOI

      10.1016/j.pupt.2014.05.006

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immunomodulatory effect of linezolid on methicillin-resistant Staphylococcus aureus supernatant-induced MUC5AC overexpression in human airway epithelial cells2014

    • Author(s)
      Kaku N, Yanagihara K, Morinaga Y, Yamada K, Harada Y, Migiyama Y, Nagaoka K, Nakamura S, Izumikawa K, Kohno S
    • Journal Title

      Antimicrob Agents Chemother

      Volume: 58 Issue: 7 Pages: 4131-4137

    • DOI

      10.1128/aac.02811-13

    • NAID

      120006986346

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Prevotella intermedia induces severe bacteremic pneumococcal pneumonia in mice with upregulated platelet-activating factor receptor expression.2014

    • Author(s)
      Nagaoka K, Yanagihara K, Morinaga Y, Nakamura S, Harada T, Hasegawa H, Izumikawa K, Ishimatsu Y, Kakeya H, Nishimura M, Kohno S
    • Journal Title

      Infect Immun

      Volume: 82 Issue: 2 Pages: 587-593

    • DOI

      10.1128/iai.00943-13

    • NAID

      120006986586

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Presentation] In Vivo Efficacy of Tedizolid (TR-701), a Novel Oxazolidinone, Against Methicillin-resistant Staphylococcus aureus in a Murine Model of Hematogenous Pulmonary Infection2014

    • Author(s)
      N. Kaku, K. Yanagihara, K. Takeda, K. Kosai, Y. Morinaga, S. Nakamura, T. Miyazaki, K. Izumikawa, S. Kohno
    • Organizer
      54th ICAAC
    • Place of Presentation
      Washington DC(米国)
    • Year and Date
      2014-09-05 – 2014-09-09
    • Related Report
      2014 Annual Research Report
  • [Presentation] 病態理解に基づく肺炎診断・治療への展開

    • Author(s)
      森永芳智,柳原克紀
    • Organizer
      第87回日本感染症学会学術講演会・第61回日本化学療法学会総会
    • Place of Presentation
      パシフィコ横浜(横浜市)
    • Related Report
      2013 Research-status Report

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Published: 2014-07-25   Modified: 2019-07-29  

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