The pathogenesis of severe infections and the immunity in respiratory tract - New approach for anti-inflammatory treatment -
Project/Area Number |
25860830
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Research Category |
Grant-in-Aid for Young Scientists (B)
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Allocation Type | Multi-year Fund |
Research Field |
Infectious disease medicine
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Research Institution | Nagasaki University |
Principal Investigator |
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Project Period (FY) |
2013-04-01 – 2015-03-31
|
Project Status |
Completed (Fiscal Year 2014)
|
Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2013: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
|
Keywords | HMGB1 / 細胞死 / 気道免疫 / マクロライド / 肺炎 / 重症化 / 気道上皮 |
Outline of Final Research Achievements |
TNFα contributes to the inhibition of bacterial growth in cells with inducting apoptotic cell death. Anaerobes produces some toxins and they may induces the receptors on the airway, which pneumococcus requires to attach to the respiratory tract. The toxins produced by anaerobes can progress the severity of pneumococcal pneumonia. The severity of infection may affect the effectiveness of antimicrobials in the treatment of pneumonia. Therefore, we need further studies for the evaluation of severity of infections and progress the strategies of choice the appropreate treatment.
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Report
(3 results)
Research Products
(6 results)
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[Journal Article] Azithromycin inhibits MUC5AC induction via multidrug-resistant Acinetobacter baumannii in human airway epithelial cells.2014
Author(s)
Yamada K, Morinaga Y, Yanagihara K, Kaku N, Harada Y, Uno N, Nakamura S, Imamura Y, Hasegawa H, Miyazaki T, Izumikawa K, Kakeya H, Mikamo H, Kohno S
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Journal Title
Pulm Pharmacol Ther
Volume: 28
Issue: 2
Pages: 165-170
DOI
Related Report
Peer Reviewed
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[Journal Article] Prevotella intermedia induces severe bacteremic pneumococcal pneumonia in mice with upregulated platelet-activating factor receptor expression.2014
Author(s)
Nagaoka K, Yanagihara K, Morinaga Y, Nakamura S, Harada T, Hasegawa H, Izumikawa K, Ishimatsu Y, Kakeya H, Nishimura M, Kohno S
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Journal Title
Infect Immun
Volume: 82
Issue: 2
Pages: 587-593
DOI
NAID
Related Report
Peer Reviewed
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[Presentation] In Vivo Efficacy of Tedizolid (TR-701), a Novel Oxazolidinone, Against Methicillin-resistant Staphylococcus aureus in a Murine Model of Hematogenous Pulmonary Infection2014
Author(s)
N. Kaku, K. Yanagihara, K. Takeda, K. Kosai, Y. Morinaga, S. Nakamura, T. Miyazaki, K. Izumikawa, S. Kohno
Organizer
54th ICAAC
Place of Presentation
Washington DC(米国)
Year and Date
2014-09-05 – 2014-09-09
Related Report
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