Roll of HMGB1 and innate immune system in vasculitis of Kawasaki disease
| Project/Area Number |
25860843
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000)
Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
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| Keywords | 川崎病 / 血管炎 / 冠動脈 / 自然免疫 / HMGB1 |
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| Outline of Final Research Achievements |
We investigated the roll of HMGB1 in vasculitis of Kawasaki disease using CAWS-induced mouse model. Treatment by anti-HMGB1 antibodies significantly reduced the inflammation score of vasculitis, and also reduced the level of IL-6 in CAWS-treated mice. We also revesled that HMGB1 is highly expressed in the lesion of vasculits of mice using immunohistochemistry. We elucidated that HMGB1 plays a critical roll in the vasculitis of the murine model of Kawasaki disease.
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Report
(3 results)
Research Products
(3 results)
