Roll of HMGB1 and innate immune system in vasculitis of Kawasaki disease

Research Project

Project/Area Number	25860843
Research Category	Grant-in-Aid for Young Scientists (B)
Allocation Type	Multi-year Fund
Research Field	Pediatrics
Research Institution	The University of Tokyo
Principal Investigator	HIRATA Yoichiro 東京大学, 医学部附属病院, 講師 (40447397)
Project Period (FY)	2013-04-01 – 2015-03-31
Project Status	Completed (Fiscal Year 2014)
Budget Amount *help	¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000) Fiscal Year 2014: ¥1,820,000 (Direct Cost: ¥1,400,000、Indirect Cost: ¥420,000) Fiscal Year 2013: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Keywords	川崎病 / 血管炎 / 冠動脈 / 自然免疫 / HMGB1
Outline of Final Research Achievements	We investigated the roll of HMGB1 in vasculitis of Kawasaki disease using CAWS-induced mouse model. Treatment by anti-HMGB1 antibodies significantly reduced the inflammation score of vasculitis, and also reduced the level of IL-6 in CAWS-treated mice. We also revesled that HMGB1 is highly expressed in the lesion of vasculits of mice using immunohistochemistry. We elucidated that HMGB1 plays a critical roll in the vasculitis of the murine model of Kawasaki disease.

Report

(3 results)