| Project/Area Number |
25860846
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pediatrics
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| Research Institution | National Research Institute for Child Health and Development (2014)
Tokyo Medical and Dental University (2013) |
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Principal Investigator |
TOMIZAWA Daisuke 独立行政法人国立生育医療研究センター, 小児がんセンター, 医長 (50401336)
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| Co-Investigator(Renkei-kenkyūsha) |
MIYAMURA Takako 大阪大学, 大学院医学系研究科・小児科, 助教 (20379796)
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| Project Period (FY) |
2013-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
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| Keywords | 乳児 / 急性リンパ性白血病 / MLL / 同種造血幹細胞移植 / KIR |
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| Outline of Final Research Achievements |
Because outcome of infants with acute lymphoblastic leukemia (ALL) and MLL gene rearrangement is dismal, we conducted a retrospective analysis evaluating significance of hematopoietic stem cell transplantation (HSCT) with killer immunoglobulin-like receptor (KIR)-ligand mismatched donor. Of the 23 patients whose data were available, five were transplanted from KIR-mismatched donor and 18 from matched donor. Survival and event-free survival of mismatched cases were 100% and 80.0%, respectively, while those of matched cases were 8.3% and 44.4%, although statistically not significant. Incidence of both acute and chronic GVHD was equal. Our results indicate the effectiveness of KIR-ligand mismatched HSCT for infant ALL and warrant further evaluation.
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