| Budget Amount *help |
¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2015: ¥1,040,000 (Direct Cost: ¥800,000、Indirect Cost: ¥240,000)
Fiscal Year 2014: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2013: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
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| Outline of Final Research Achievements |
Recently, epicutaneous sensitization has got attention as a novel sensitization pathway for food allergy. We established a murine model of food allergy caused by epicutaneous sensitization, in which antigen and vitamin D3 analog (MC903) as an adjuvant were epicutaneously administered and then the antigen was orally challenged to induce immediate type of allergic diarrhea. Repetitive oral challenges increased serum levels of mucosal mast cell protease-1, which correlated with the severity of induced symptoms. Th2 cytokine mRNA expression was increased in the skin. Th2 reactions in skin and activation of mucosal mast cells may play important roles in the development of food allergy. Their regulation might alleviate induced food allergy symptoms.
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