Elucidation of the role of redox-active protein in severe influenza (pneumonia, encephalopathy)

• Project/Area Number: 25860865
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Okayama University
• Principal Investigator: Yashiro Masato 岡山大学, 大学病院, 助教 (80585943)
• Research Collaborator: YAMADA Mutsuko 岡山大学, 大学院医歯薬学総合研究科・小児科, 非常勤研究員 ; FUJII Yousuke 岡山大学, 大学院医歯薬学総合研究科・小児科, 助教 (80549775) ; NOSAKA Nobuyuki 岡山大学病院, 小児科, 医員 (30713961) ; TSUKAHARA Hirokazu 岡山大学, 大学院医歯薬学総合研究科小児医科学, 教授 (90207340) ; MORISHIMA Tsuneo 岡山大学, 大学院医歯薬学総合研究科小児医科学, 特命教授 (90157892)
• Project Period (FY): 2013-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000); Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000); Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000); Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
• Keywords: 小児感染症学 / インフルエンザ / 酸化ストレス

Outline of Final Research Achievements

TBP2KO mouse was suggested possibility of a metabolic disorder type influenza encephalopathy (Reye syndrome) model mice. In addition redox-active protein of TRX and anti-HMGB1 antibody has been shown to be effective in severe influenza pneumonia in mice. It is expected to confirm the therapeutic effect using a drug with anti-oxidative and anti-inflammatory effect in encephalopathy model mice.

Research Products

• [Journal Article] Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice (2015)
  • Author(s): Nosaka N, Yashiro M, Yamada M, Fujii Y, Tsukahara H, Liu K, Nishibori M, Matsukawa A, Morishima T
  • Journal Title: Critical Care Volume: 19 Issue: 1 Pages: 249-249
  • DOI: 10.1186/s13054-015-0983-9
  • Peer Reviewed / Open Access
• [Journal Article] Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor. (2015)
  • Author(s): Saito Y, Fujii Y, Yashiro M, Tsuge M, Nosaka N, Yamashita N, Yamada M, Tsukahara H, Morishima T.
  • Journal Title: Acta Med Okayama Volume: 69 Pages: 279-290
  • NAID: 120005666066
  • Peer Reviewed / Open Access
• [Book] Oxidative Stress and Antioxidant Protection -Disorders of children (2016)
  • Author(s): Hirokazu Tsukahara ,Masato Yashiro
  • Total Pages: 600
  • Publisher: Willey Blackwell
• [Book] 医学のあゆみ レドックスUPDATE インフルエンザ急性肺障害におけるチオレドキシン（TRX-1）の役割 (2015)
  • Author(s): 八代将登、森島恒雄
  • Total Pages: 341
  • Publisher: 医歯薬出版株式会社