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Elucidation of the role of redox-active protein in severe influenza (pneumonia, encephalopathy)

Research Project

Project/Area Number 25860865
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Pediatrics
Research InstitutionOkayama University

Principal Investigator

Yashiro Masato  岡山大学, 大学病院, 助教 (80585943)

Research Collaborator YAMADA Mutsuko  岡山大学, 大学院医歯薬学総合研究科・小児科, 非常勤研究員
FUJII Yousuke  岡山大学, 大学院医歯薬学総合研究科・小児科, 助教 (80549775)
NOSAKA Nobuyuki  岡山大学病院, 小児科, 医員 (30713961)
TSUKAHARA Hirokazu  岡山大学, 大学院医歯薬学総合研究科小児医科学, 教授 (90207340)
MORISHIMA Tsuneo  岡山大学, 大学院医歯薬学総合研究科小児医科学, 特命教授 (90157892)
Project Period (FY) 2013-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2015: ¥650,000 (Direct Cost: ¥500,000、Indirect Cost: ¥150,000)
Fiscal Year 2014: ¥1,170,000 (Direct Cost: ¥900,000、Indirect Cost: ¥270,000)
Fiscal Year 2013: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Keywords小児感染症学 / インフルエンザ / 酸化ストレス
Outline of Final Research Achievements

TBP2KO mouse was suggested possibility of a metabolic disorder type influenza encephalopathy (Reye syndrome) model mice. In addition redox-active protein of TRX and anti-HMGB1 antibody has been shown to be effective in severe influenza pneumonia in mice. It is expected to confirm the therapeutic effect using a drug with anti-oxidative and anti-inflammatory effect in encephalopathy model mice.

Report

(4 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Research-status Report
  • 2013 Research-status Report
  • Research Products

    (4 results)

All 2016 2015

All Journal Article (2 results) (of which Peer Reviewed: 2 results,  Open Access: 2 results) Book (2 results)

  • [Journal Article] Anti-high mobility group box-1 monoclonal antibody treatment provides protection against influenza A virus (H1N1)-induced pneumonia in mice2015

    • Author(s)
      Nosaka N, Yashiro M, Yamada M, Fujii Y, Tsukahara H, Liu K, Nishibori M, Matsukawa A, Morishima T
    • Journal Title

      Critical Care

      Volume: 19 Issue: 1 Pages: 249-249

    • DOI

      10.1186/s13054-015-0983-9

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inhibitory Effects of Edaravone, a Free Radical Scavenger, on Cytokine-induced Hyperpermeability of Human Pulmonary Microvascular Endothelial Cells:A Comparison with Dexamethasone and Nitric Oxide Synthase Inhibitor.2015

    • Author(s)
      Saito Y, Fujii Y, Yashiro M, Tsuge M, Nosaka N, Yamashita N, Yamada M, Tsukahara H, Morishima T.
    • Journal Title

      Acta Med Okayama

      Volume: 69 Pages: 279-290

    • NAID

      120005666066

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Book] Oxidative Stress and Antioxidant Protection -Disorders of children2016

    • Author(s)
      Hirokazu Tsukahara ,Masato Yashiro
    • Total Pages
      600
    • Publisher
      Willey Blackwell
    • Related Report
      2015 Annual Research Report
  • [Book] 医学のあゆみ レドックスUPDATE インフルエンザ急性肺障害におけるチオレドキシン(TRX-1)の役割2015

    • Author(s)
      八代将登、森島恒雄
    • Total Pages
      341
    • Publisher
      医歯薬出版株式会社
    • Related Report
      2015 Annual Research Report

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Published: 2014-07-25   Modified: 2019-07-29  

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